OBJECTIVE : To study the safety and efficacy of methylphenidate in children with the dual diagnosis of epilepsy and attention deficit hyperactivity disorder ( ADHD ) .
CONCLUSION : Methylphenidate is effective in treating children with epilepsy and ADHD and safe in children who are seizure free .
BACKGROUND : Antiplatelet therapy with aspirin and systematic anticoagulation with warfarin reduce cardiovascular morbidity and mortality after myocardial infarction when given alone .
At 293 sites , we randomly assigned 8803 patients who had had myocardial infarction , treatment with 160 mg aspirin , 3 mg warfarin with 80 mg aspirin , or 1 mg warfarin with 80 mg aspirin .
INTERPRETATION : Low , fixed-dose warfarin ( 1 mg or 3 mg ) combined with low-dose aspirin ( 80 mg ) in patients who have had myocardial infarction does not provide clinical benefit beyond that achievable with 160 mg aspirin monotherapy .
METHODS : The effect of roxithromycin was assessed in a double-blind , randomised , prospective , multicentre , parallel-group , placebo-controlled pilot study of 202 patients with unstable angina or non-Q-wave myocardial infarction .
INTERPRETATION : Antichlamydial antibiotics may be useful in therapeutic intervention in addition to standard medication in patients with coronary-artery disease .
BACKGROUND : Stage Ib and IIa cervical carcinoma can be cured by radical surgery or radiotherapy .
This study is designed to investigate the immediate effectiveness of electrotherapy on myofascial trigger points of upper trapezius muscle .
It is concluded that ENS is more effective for immediate relief of myofascial trigger point pain than EMS , and EMS has a better effect on immediate release of muscle tightness than ENS .
OBJECTIVES : Obesity is an important clinical problem , and the use of dexfenfluramine hydrochloride for weight reduction has been widely publicized since its approval by the Food and Drug Administration .
The manufacturer claims that moxonidine `` accurately targets imidazoline receptors at the cardiovascular control centre in the brainstem '' and is `` as effective as current first-line therapies for essential hypertension `` .
In order to evaluate the applicability of anthelminthic treatment of wild foxes ( Vulpes vulpes ) to limit their infection with Echinococcus multilocularis , bait pellets , each containing 50 mg praziquantel , were repeatedly distributed in an area of 566 km2 where many foxes are infected , in southern Germany .
We assessed G-CSF as adjuvant therapy for the treatment of severe foot infections in diabetic patients .
INTERPRETATION : G-CSF treatment was associated with improved clinical outcome of foot infection in diabetic patients .
BACKGROUND : Accelerated infusion of alteplase ( tissue plasminogen activator ) over a period of 90 minutes induces more rapid lysis of coronary-artery thrombi than a 3-hour infusion .
METHODS : In 398 hospitals , 7169 patients with acute myocardial infarction were randomly assigned to weight-adjusted , accelerated infusion of 100 mg of alteplase or to a bolus of 50 mg of alteplase over a period of 1 to 3 minutes followed 30 minutes later by a second bolus of 50 mg ( or 40 mg for patients who weighed less than 60 kg ) .
Successful arthrodesis was achieved in all five feet in patients with rheumatoid arthritis .
A prospective , randomized , placebo-controlled , double-blind , parallel-group , 6-month study assessed the efficacy and safety of ropinirole , a nonergoline D2-dopamine agonist , in patients with early Parkinson 's disease ( n = 241 ; Hoehn & # 38 ; Yahr stages I to III ) with limited or no prior dopaminergic therapy .
Ropinirole monotherapy is an effective and well-tolerated therapeutic option for treatment of early Parkinson 's disease .
METHODS : We reviewed the charts of 20 eyes of 15 children ( aged 1.5 to 2 years ) who had primary cataract surgery with PC IOL implantation during the past 5 years .
OBJECTIVE : To assess the medicalising effect of prescribing antibiotics for sore throat .
DESIGN : Randomised trial of three approaches to sore throat : a 10 day prescription of antibiotics , no antibiotics , or a delayed prescription if the sore throat had not started to settle after three days .
Antibiotics prescribed for sore throat during the previous year had an additional effect ( hazard ratio 1.69 , 1.20 to 2.37 ) .
CONCLUSIONS : Complications and early return resulting from no or delayed prescribing of antibiotics for sore throat are rare .
This study was designed to determine and compare the dose-response characteristics , speed of onset , and relative potency of single-dose epidural fentanyl ( F ) and sufentanil ( S ) for postoperative pain relief .
PURPOSE : The American Urological Association convened the Female Stress Urinary Incontinence Clinical Guidelines Panel to analyze the literature regarding surgical procedures for treating stress urinary incontinence in the otherwise healthy female subject and to make practice recommendations based on the treatment outcomes data .
MATERIALS AND METHODS : The panel searched the MEDLINE data base for all articles through 1993 on surgical treatment of female stress urinary incontinence .
CONCLUSIONS : The panel found sufficient acceptable long-term outcomes data ( longer than 48 months ) to conclude that surgical treatment of female stress urinary incontinence is effective , offering a long-term cure in a significant percentage of women .
The evidence supports surgery as initial therapy and as a secondary form of therapy after failure of other treatments for stress urinary incontinence .
In women with primary infertility all pregnancies achieved by either partner or donor intrauterine insemination carried to birth of a fetus ( > 20 weeks ) were identified .
RESULTS : Forty-four patients in the partner intrauterine insemination group and 37 in the donor insemination group were identified as having primary infertility .
Because exploratory celiotomy is routinely performed on patients with gunshot wounds to the abdomen , DPL is rarely employed .
BACKGROUND : Thrombolytic treatment has been shown to accelerate resolution of major pulmonary embolism and lead to a rapid improvement of right-side hemodynamics .
CONCLUSIONS : The results of our study suggest that thrombolysis may favorably affect the clinical outcome of hemodynamically stable patients with major pulmonary embolism .
A 66-year-old male engineer diagnosed with malignant pleural mesothelioma 4 years previously had thoracotomy , radiotherapy , and chemotherapy .
The authors report the postoperative magnetic resonance ( MR ) imaging findings in 36 patients with advanced Parkinson 's disease who underwent unilateral microelectrode-guided posteroventral pallidotomy .
The efficiency of testicular sperm retrieval by testicular fine needle aspiration ( TEFNA ) was compared with open biopsy and testicular sperm extraction ( TESE ) , in 37 rigorously selected patients with non-obstructive azoospermia .
The treatment of diabetes 2 by the classic oral antidiabetic drugs ( sulfamides and biguanides ) is completed by intestinal glycosidases inhibitors and thiazolidendiones .
Calcium antagonists have been used for treatment of cardiovascular diseases for more than 25 years .
In addition , well-conducted studies using verapamil and diltiazem have suggested that these calcium antagonists may even improve cardiovascular mortality and morbidity of the hypertensive patient .
Sumatriptan and other selective serotonin agonists represent a major breakthrough in acute migraine treatment .
Control of post-haemorrhoidectomy bleeding with a Foley catheter and a pack .
Behavior of the tetanus patient subjected to resuscitation treatment
Long term results in the 300 most grave cases out of 4000 hyperthyroid patients treated with iodine I-131 at the center of Ancona
Prolonged cortisone therapy in treatment of allergic diseases
The rationale of extended resection for complicated cancer of the large bowel .
Medical treatment of stone disease .
Surgical treatment of urinary stones .
Hyperbaric oxygen , whole-body X irradiation , and cyclophosphamide combination therapy in mouse leukemia L1210 .
Possibilities of surgical correction of malformations of the bones of the foot
Fish protein concentrates in the treatment of kwashiorkor .
Treatment of cavernous hemangiomas with the neodymium : YAG laser
Issues regarding antiretroviral treatment for patients with HIV-1 infection .
Treatment of verruca vulgaris with topical cidofovir .
Elective surgery for colorectal cancer in the aged : a clinical-economical evaluation .
Elective surgery for gastrointestinal tumours in the elderly .
Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction .
Randomised trial of roxithromycin in non-Q-wave coronary syndromes : ROXIS Pilot Study .
Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer .
Another use of androgens : treatment of anemia of end-stage renal disease .
Antimicrobial therapy in neutropenia
Moxonidine for hypertension .
Chemotherapy with praziquantel has the potential to reduce the prevalence of Echinococcus multilocularis in wild foxes ( Vulpes vulpes ) .
Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection .
A comparison of continuous infusion of alteplase with double-bolus administration for acute myocardial infarction .
Antibiotic management of sore throat .
Cancer therapy and tumor physiology .
Phototherapeutic keratectomy in recurrent corneal erosions refractory to other forms of treatment .
Arthrodesis of the first metatarsophalangeal joint to salvage failed silicone implant arthroplasty .
Ropinirole for the treatment of early Parkinson 's disease .
Non-steroidal anti-inflammatory therapy for bronchial asthma .
Female Stress Urinary Incontinence Clinical Guidelines Panel summary report on surgical management of female stress urinary incontinence .
Back from the dead : extracorporeal rewarming of severe accidental hypothermia victims in accident and emergency .
Randomised controlled trial of magnetic-resonance pelvimetry in breech presentation at term .
Role of fine needle aspiration cytology in the management of the discrete parotid lump .
More than 20 years second-look surgery in advanced epithelial ovarian cancer : what did we learn ?
Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson 's disease : postoperative magnetic resonance imaging analysis .
Follow up after potential curative surgery of colorectal cancer .
Lung volume reduction surgery for emphysema .
Shark cartilage for cancer ?
Testicular sperm retrieval by percutaneous fine needle sperm aspiration compared with testicular sperm extraction by open biopsy in men with non-obstructive azoospermia .
The effect of TRK-530 on experimental arthritis in mice .
Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone .
Homeopathy for postoperative ileus ? A meta-analysis .
Inositol treatment of autism .
Role of beta-blockers in the treatment of cardiac insufficiency
Which calcium antagonists for hypertension ?
Correct use of serotonin agonists in migraine : oral or injectable form ?
Surgical management of soft tissue sarcomas : principles of resection and reconstructive plastic procedures
Adjuvant chemotherapy in early soft tissue sarcoma and palliative chemotherapy in advanced soft tissue sarcoma in adults
Radiotherapy of soft tissue sarcomas
Case of superficial hemosiderosis of the central nervous system treated with trientine
Zinc gluconate lozenges for treating the common cold .
Use of protein-C concentrate , heparin , and haemodiafiltration in meningococcus-induced purpura fulminans .
Modulation of ultraviolet light-induced epidermal damage : beneficial effects of tocopherol .
Use of cisapride in treatment of constipation in children .
Multicenter study of surfactant ( beractant ) use in the treatment of term infants with severe respiratory failure .
Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir .
External beam radiation therapy for choroidal neovascularization .
Bolus thrombolytic infusions during CPR for patients with refractory arrest rhythms : outcome of a case series .
Use of a nerve stimulator for phrenic nerve block in treatment of hiccups .
Anaesthesia for laparoscopic cholecystectomy in a patient with Eisenmenger 's syndrome .
Clinical evaluation of adjuvant chemoradiotherapy with CDDP , 5-FU , and VP-16 for advanced esophageal cancer .
New drug treatment for Alzheimer 's disease : lessons for healthcare policy .
Simple antiseptic mouthwashes are best for infection .
A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina .
Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin 's lymphoma .
Endoscopic hemostasis of bleeding duodenal ulcer in a child with Henoch-Schönlein purpura .
Treatment of renal failure in idiopathic membranous nephropathy with azathioprine and prednisolone .
Chelation therapy for peripheral arterial occlusive disease : a systematic review .
Endoscopic ultrasound miniprobe-guided steroid injection for treatment of refractory esophageal strictures .
A systematic review of five systemic treatments for severe psoriasis .
Clinical management and treatment outcomes of Merkel cell carcinoma .
Inhaled sodium cromoglycate in young children with moderate asthma .
Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult .
conclusions : apc is effective for the treatment of endoluminal hemoptysis and airway obstruction
induction chemotherapy ( cisplatin + vinorelbine ) is found to be markedly effective for squamous cell lung carcinoma with sarcoidosis -- a case report
the patient was a 62-year-old man with squamous cell lung cancer , which was first successfully treated by a combination of radiation therapy and chemotherapy , but showed local recurrence after 8 months .
the combination of txt , gem and cddp may be effective for recurrent non-small-cell lung carcinoma , even in patients that have failed to respond to more than one chemotherapy regimen .
the aim of the current study was to compare the objective response and survival rates of patients with mrcc treated with il-2 administered either systemically ( syst , subcutaneously ) or via inhalation ( inh ) , using relatively large sample sizes to afford a more meaningful comparison .
conclusion : as expected , the type of chemotherapy we used , to treat non-seminomatous germ-cell tumors proved to be highly effective for seminomatous types , as well .
carboplatin and ifosfamide performed well and safe , in the treatment of non-bulky metastatic seminoma .
these results suggested that the sp1 decoy strategy would be effective for regulating tumor growth by simultaneously reducing cancer cell ( a ) angiogenic growth factor expression , ( b ) proliferation , and ( c ) invasiveness .
considering that hamsters had a lung metastasis rate of 50 % before mdp-lys treatment , liposomal mdp-lys given at a dose of 20 microg twice/week was effective for inhibiting lung metastasis at a far lower dose of mdp-lys than that given as a solution ( 40 microg vs. 350 microg per week ) .
we have documented previously that adenovirus-mediated interleukin 12 ( il-12 ) gene therapy is effective for orthotopic tumor control and suppression of pre-established metastases in a preclinical prostate cancer model ( y. nasu et al. , gene ther .
we further developed a vaccine model based on s.c.injection of infected , irradiated rm-9 cells and found that both admil-12 and admil-12/b7 are effective at suppressing the development and growth of challenge orthotopic tumors using this protocol .
despite the marked toxicity of the initial intensive chemotherapy , the treatments are tolerable and effective in the control of extra-thoracic micrometastases , whereas they are less effective for thoracic primary tumor .
radiotherapy is effective for palliation of symptoms associated with sblc .
clinically , oral administration of uft has proved to be effective as an adjuvant therapy after surgery for some malignant tumors such as non-small cell lung cancer .
moreover , uft has proved to be effective for inoperable advanced malignancies such as colorectal cancer , especially in combination with leucovorin or cisplatin .
a phase ii study of fractionated administration of irinotecan ( cpt-11 ) and cisplatin ( cddp ) in patients with non-small-cell lung cancer ( nsclc ) was conducted .
in conclusion , fractionated administration of cpt-11 and cddp was highly effective for advanced nsclc with manageable toxicities .
we report the use of paclitaxel in the successful treatment of a patient with recurrent adenocarcinoma of the cervix .
weekly paclitaxel was very well tolerated , yet was effective for recurrent cervical adenocarcinoma .
conclusion : our results suggest that pseudoephedrine plus acetaminophen is effective for relief of symptoms attributable to the paranasal sinuses that may develop early in the course of a cold .
reviewer 's conclusions : a single dose of nasal decongestant in the common cold is moderately effective for the short term relief of congestion in adults , while there is no evidence available to show benefit after repeated use over several days .
conclusions : members of an ethnically diverse community believe antibiotics are effective for colds , are very likely to seek care for colds , and often obtain antibiotics without a prescription .
intravenous injection of pb2-as , as a complex with dmrie-c , a cationic liposome , was most effective for prolonging the mean survival time in days ( msds ) and increasing the survival rates of mice infected with the influenza a virus .
background and objectives : thoracic paravertebral block ( tpvb ) is a unilateral analgesic technique that has been advocated in both acute and chronic thoracic and abdominal pain .
other blocks such as interpleural and epidural can be effectively used in pleuritic pain .
this report illustrates that tpvb could also be effective for this kind of pain .
conclusions : this case report supports the notion that , in practice , the paravertebral block could be an effective and safe alternative to relief of pleuritic pain .
conclusion : mr-guided rfa using single cooled tip electrodes is safe and technically effective for treatment of hepatic neoplasms up to 3 cm in size , however further improvements are necessary .
a 68-year-old man underwent curative pancreaticoduodenectomy for bile duct cancer .
one course of chronochemotherapy was effective for lymph node and peritoneum metastases .
the only specific antidote for dosage-dependent hepatotoxicity is n-acetylcysteine ( and some other sulfhydryl donors ) , which is highly effective for the prevention of significant hepatotoxicity after acetaminophen overdose .
corticosteroids can be considered for cases of drug-induced hepatitis , especially those with evidence of immune hypersensitivity , if no improvement is seen in 8 to 12 weeks .
our conclusion was that the covered-ems can be effective for the palliation of esophagorespiratory fistulas .
only the combination of a cell wall-active antibiotic to which the enterococcus is susceptible ( ie , certain beta-lactams or vancomycin ) plus an aminoglycoside ( ie , gentamicin or streptomycin ) is bactericidal , and is required for cure of endocarditis , meningitis and probably infection in neutropenic patients ; bacteriostatic activity is sufficient to treat most other infections .
two triazole antifungal agents , fluconazole and itraconazole , were introduced over a decade ago and since then have been used extensively for the prophylaxis and treatment of a variety of fungal infections .
the use of topical corticosteroids has revolutionised the treatment of inflammatory skin diseases .
in particular , tacrolimus and ascomycin derivatives have been shown to be effective for treating atopic dermatitism with a surprising lack of side effects .
cyclophosphamide therapy is effective for bronchiolitis obliterans occurring as a late manifestation of lupus erythematosus ( letter )
in summary , gemifloxacin was found to be well tolerated and effective for the treatment of aecb , suggesting it is well suited for empirical treatment of this common respiratory condition in the current clinical environment .
d-penicillamine ( 2-amino-3-mercapto-3-methylbutanoic acid ) , a well-known heavy metal chelator , is the drug of choice in the treatment of wilson 's disease and is also effective for the treatment of several disorders including rheumatoid arthritis , primary biliary cirrhosis , scleroderma , fibrotic lung diseases and progressive systemic sclerosis .
stages of non-small cell lung cancer ( nsclc ) that are potential candidates for surgical resection have been treated in several ways : surgery alone is curative in only two-thirds of cases and post-operative radiotherapy ( rt ) provides only weak control of advanced-stage disease .
among these , the gemcitabine/cisplatin study protocol ( gc ) , set up in a phase ii study for patients with stage iiia n2 nsclc , was very effective ( objective response ( or ) : 70.2 % ; median survival : 19 months ) and should be promising for stages ib and ii .
several studies have suggested that non-small cell lung cancer ( nsclc ) patients whose tumors have neuroendocrine ( ne ) features may be more responsive to chemotherapy in addition , increased expression of p53 and her2 may confer relative chemotherapy resistance and shortened survival .
the cancer and leukemia group b performed a series of studies involving sequential chemotherapy followed by radiation for patients with unresectable stage iii nsclc .
this london lung cancer group trial of gemcitabine/carboplatin may define an active , safe , and acceptable treatment for patients with extensive-stage and poor-prognosis small cell lung cancer .
gemcitabine and carboplatin for patients with advanced non-small cell lung cancer
an aggressive surgical approach is justified in patients with mplc and offers the greatest chance for long-term survival even in the case of limited resection .
methods and materials : eleven patients with small cell lung cancer ( sclc ) , who had presented complete response of disease after chemotherapy and radical radiotherapy in the lung , were prescribed to receive a prophylacting cranial irradiation ( pci ) with a 6 mev linear accelerator .
only 22 patients ( 10 % ) were alive at five years : 19 patients with nsclc who had got surgical treatment , one patient with nsclc ( stage iiib ) who had recieved radiotherapy , and two patients with sclc , limited disease , treated with chemo- and radiotherapy .
five new agents , paclitaxel , docetaxel , vinorelbine , gemcitabine and irinotecan , have been introduced for the treatment of nsclc and investigated extensively both preclinically and clinically .
whether the era of platinum-based chemotherapy in the treatment of nsclc should continue or not must be determined by phase iii trials , evaluating the use of a platinum agent with one of the new agent combinations .
these aggressive chemotherapeutic combinations will hopefully improve survival and quality of life for patients with advanced nsclc .
results : we have performed 60 carinal resections for bronchogenic carcinoma : 18 isolated carinal resections for tumor confined to the carinal or proximal main stem bronchus ; 35 carinal pneumonectomies ; 5 carinal plus lobar resections , and 2 carinal resections for stump recurrence after prior pneumonectomy .
conclusions : this constitutes one of the largest single-institution reports on carinal resection for bronchogenic carcinoma involving the carina .
extracorporeal photopheresis has evolved as a possible therapy for patients with acute nd chronic lung allograft rejection .
methods : we retrospectively reviewed 14 patients diagnosed with bos who underwent therapy with extracorporeal photopheresis .
in three patients with bos and concurrent acute rejection , therapy with extracorporeal photopheresis led to the resolution of the acute rejection episode .
conclusion : extracorporeal photopheresis appears to be a promising therapy for patients with early bos .
purpose : many patients with locally advanced non-small-cell lung cancer ( la-nsclc ) are eligible for combined-modality therapy ( cmt ; chemotherapy and radiotherapy ) .
over the past twenty years combination chemotherapy has continued to produce small survival gains for patients with sclc .
extent of pulmonary involvement at diagnosis , response of pm after induction chemotherapy , local treatment of pm thereafter , and clinical outcome were recorded .
conclusions : the comparable survival of patients with poor and good response of pm to induction chemotherapy suggests that wli may benefit poor responders .
objective : to report the use of heparin and enoxaparin for radiation-induced myelopathy .
therefore , patients with radiation-induced spinal cord injury may benefit from anticoagulant therapy .
conclusions : heparin and/or enoxaparin may be considered as potential treatments for patients with radiation-induced myelopathy .
expandable metal stents were inserted in two patients with severe dyspnea due to tracheal stenosis caused by lung cancer and esophageal cancer .
thus , we should recognize this immanent risk and perform peri- and postoperative management for patients with gh-producing tumors .
background : at present the addition of thoracic irradiation to combination chemotherapy is a standard treatment for limited staged small cell lung cancer .
we conducted a phase ii study of etoposide ( vp-16 ) -ifosfamide-cisplatin ( vip ) combination chemotherapy plus early concurrent thoracic irradiation for the patients with previously untreated limited small cell lung cancer in order to assess if the treatment modality could improve the response rate and the toxicity .
methods : forty-four patients with limited small cell lung cancer were treated with etoposide-ifosfamide-cisplatin and concurrent thoracic irradiation .
conclusion : vip combination chemotherapy and early concurrent thoracic irradiation for patients with limited stage small cell lung cancer revealed excellent antitumor response with tolerable toxicity .
in this study we analyzed 33 cases which underwent complete surgical resection to assess the role of surgery in the treatment of patients with n 2 nsclc .
we thereby recommend that surgery should only be performed for those n 2 nsclc patients diagnosed as t 1 or t 2 with a classification of p1 or less .
inhaled corticosteroid therapy is recommended for patients with persistent disease , and careful instruction in the use of metered-dose inhalers is particularly important for the elderly .
background : the role of surgical staging of patients with non-small cell lung cancer ( nsclc ) continues to evolve .
purpose : given the cisplatin-related myelotoxicity and nonhematologic toxicities , we were prompted to undertake a study of the noncisplatin combination of paclitaxel plus gemcitabine to evaluate the efficacy , tolerance , and survival of this combination in patients with locally advanced and metastatic non-small-cell lung cancer ( nsclc ) .
we evaluated the role of systemic chemotherapy for patients with malignant pleural effusions from nsclc .
methods : we analyzed 34 patients who were found to have malignant pleural effusions in the course of diagnosis of 118 patients enrolled in three consecutive clinical trials on advanced nsclc assessing combination chemotherapy of cisplatin , ifosfamide , and irinotecan with recombinant human granulocyte colony-stimulating factor support .
conclusions : both the response rate and survival data in this retrospective study suggest a high degree of activity of this combination chemotherapy in patients with malignant pleural effusions from nsclc .
in contrast , the introduction and improvement of chemotherapy since the 1970s gave rise to an improvement in - only short-term ( < 2 years ) - survival for patients with small-cell lung cancer .
between july 1992 and december 1997 , 1799 patients were diagnosed as having lung cancer in our hospital and 926 patients received chemotherapy and/or thoracic radiotherapy .
the administration of mitomycin c in addition to cisplatin-based regimens for patients with lung cancer should be carefully considered .
570 patients with osteosarcoma of the extremities were treated with five different protocols of neoadjuvant chemotherapy at rizzoli institute between 1983 and 1995 .
we conclude that for patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy : ( a ) the pattern of systemic relapse changes according to the efficacy of the protocol of chemotherapy used .
the degree of healing and damage of the bronchial wall after photodynamic therapy , nd-yag laser and electrocautery for intraluminal early-stage cancer have been analysed .
to examine whether efficacy of postoperative oral administration of uft , a 5-fluorouracil derivative chemotherapeutic agent , may be influenced by incidence of apoptosis ( apoptosis index ) or apoptosis-related gene status ( p53 and bcl-2 ) of the tumour , a total of 162 patients with pathologic stage i non-small cell lung cancer were retrospectively reviewed .
objectives : the purpose of this study is to review our experience with the spectrum of neuroendocrine neoplasms of the lung with emphasis on the histopathologic classification and surgical therapy of each class of neoplasm .
patients : during this period , a total of 77 patients underwent lung resection for the following neuroendocrine neoplasms : typical carcinoid ( tc ) , 50 patients ; atypical carcinoid ( ac ) , 5 patients ; large cell neuroendocrine carcinoma ( lcnec ) , 9 patients ; mixed large-small cell neuroendocrine carcinoma ( lsnec ) , 4 patients ; or small cell neuroendocrine carcinoma ( scc ) , 9 patients .
despite the poor overall prognosis in high-grade neuroendocrine tumors of the lung , surgery remains a viable adjunct in the early stages of this disease .
urpose : to assess results with twice-daily high-dose radiotherapy ( rt ) for non-small-cell lung cancer ( nsclc ) .
is prolonged survival possible for patients with supraclavicular node metastases in nsclc treated with chemoradiotherapy ? ijrobp 1999 ; 44 ( 4 ) : 847-853 .
we aimed to investigate whether biological factors related to radiosensitivity and chemosensitivity have prognostic significance in non-small-cell-lung-cancer ( nsclc ) patients treated with daily low doses of cisplatin and radiotherapy .
we treated 27 nsclcm patients with concomitant daily low-dose cisplatin and radiotherapy between 1993 and 1995 .
background : we examined the complications and outcomes of placing stents for both esophageal and tracheobronchial stenoses .
methods : we placed stents for both esophageal and tracheobronchial stenoses in 8 patients ( 7 with esophageal cancer and 1 with lung cancer ) .
covered or noncovered metallic stents were used for the esophageal stenoses , except in 1 patient treated with a silicone stent .
silicone stents were used for the tracheobronchial stenoses .
results : all patients experienced improvement of grades of both dysphagia and respiratory symptoms after stent therapy .
conclusions : for patients with both esophageal and tracheobronchial stenoses , a stent should be introduced into the tracheobronchus first .
because placement of stents in both the esophagus and tracheobronchus has a high risk of enlargement of the fistula , a covered metallic stent is preferable for esophageal cancer involving the tracheobronchus .
a retrospective immunohistochemical study was performed on material from patients who were newly diagnosed with osteogenic sarcoma who were treated according to the t12 protocol from the authors ' institution between 1986 to 1993 .
these data suggest that her2/erbb-2 should be evaluated prospectively as a prognostic indicator and clinical trials using antibodies that target this receptor should be considered for the treatment of patients with osteogenic sarcoma .
objective : to examine the effectiveness of ninjin yoei to ( nyt ; ren-shen-yang-rong-tang in chinese medicine ; kotaro pharmaceutical co. , ltd. , osaka , japan ) , one of the traditional herbal medicines , against lung carcinoma .
setting : the nursing center himawari design , patient , and preparation : the regular dosage of nyt ( 15 g/d ) was prescribed for 7 weeks to one elderly patient with lung carcinoma .
conclusion : nyt has a positive effect on life expectancy for patients with malignancy .
background : the costs of videothoracoscopic procedures for patients with lung carcinoma were compared with those of patients who underwent open thoracotomy in japan .
methods : the cost of surgical treatment in 1997 and 1998 for patients with resectable primary or metastatic lung carcinoma was analyzed from itemized statements of hospital charges .
for patients with lung carcinoma who are in relatively poor health , the authors chose videothoracoscopic lobectomy or partial resection of the lung instead of an open thoracotomy .
for patients with solitary pulmonary metastasis , the authors routinely performed thoracoscopic partial resection of the lung .
background : curative therapy is available for patients with stage 0 lung carcinoma , with a > 90 % 5-year survival rate .
object : the purpose of this retrospective study was to compare the effectiveness of gamma knife radiosurgery ( gks ) for multiple cerebral metastases with that of whole-brain radiation therapy ( wbrt ) .
in the gks group , large lesions ( > 30 mm ) were removed surgically and all other small lesions ( < or = 30 mm ) were treated by gks .
new distant lesions were treated by repeated gks without prophylactic wbrt .
conclusions : gamma knife radiosurgery without prophylactic wbrt could be a primary choice of treatment for patients with as many as 10 cerebral metastases from nonsmall cell cancer .
the notable exception has been docetaxel , which has been extensively studied as a second-line therapy for nsclc .
object : the purpose of this retrospective study was to compare the effectiveness of gamma knife radiosurgery ( gks ) for multiple cerebral metastases with that of whole-brain radiation therapy ( wbrt ) .
patients with a single non-sclc , breast , melanoma , renal cell , and ovarian carcinoma brain metastasis have the best chance for long-term survival if treated with surgical resection and wbrt .
objective : careful patient selection is vital when video-assisted thoracoscopic surgical ( vats ) therapeutic pulmonary metastasectomy of colorectal carcinoma is considered .
we reviewed our vats experience for therapeutic metastasectomy of peripheral colorectal pulmonary metastases .
methods : over 90 months , therapeutic vats metastasectomy was accomplished upon 80 patients with colorectal metastases .
conclusions : therapeutic vats resection of colorectal metastases appears efficacious .
objectives : to review the spectrum of presentation and the surgical management of non small cell lung cancer ( nsclc ) and the role of various diagnostic modalities in predicting the post-operative stage and the correlation of the post-operative stage with the chances of recurrence .
patients with limited-stage small-cell carcinoma of the lung are treated with combined-modality therapy with the intent to cure .
in the past several years , new chemotherapeutic agents , including the taxanes and the topoisomerase i inhibitors , have demonstrated substantial activity against small-cell carcinoma .
we evaluated the role of chemotherapy for patients with brain metastases from nsclc .
methods : we analyzed 30 patients who were discovered to have brain metastases during the diagnosis of 121 patients enrolled in three consecutive clinical trials on advanced nsclc assessing combination chemotherapy of cisplatin , ifosfamide and irinotecan with rhg-csf support .
conclusions : both the response rate and survival data in this retrospective study suggest a high degree of activity of this combination chemotherapy in patients with brain metastases from nsclc .
the aim of this study was the evaluation of both the antitumour activity and toxicity of an immunochemotherapeutic regimen consisting of interferon-alpha2b and interleukin-2 in combination with fotemustine for patients with metastatic melanoma .
to explore the induction of chemotherapy ( ct ) dna damage and its correlation with tumor response and patient survival , we undertook the present study in 20 small cell lung cancer ( sclc ) patients .
in patients with metastatic colorectal cancer , intravenous oxaliplatin has been trialled as a monotherapy and in combination with other agents .
neoadjuvant therapy with oxaliplatin/fluorouracil/folinic acid has proven beneficial in enabling surgical removal of previously unresectable liver metastases .
in 2 studies , surgery with curative intent was performed in 16 and 51 % of patients with initially unresectable liver metastases following oxaliplatin/fluorouracil/folinic acid therapy ; the 5-year survival rates were 40 and 50 % , respectively .
in patients with advanced ovarian cancer , first-line therapy with oxaliplatin/cyclophosphamide achieved an objective response rate which did not differ significantly from that of cisplatin/cyclophosphamide ( 33 vs 42 % ) .
in addition , oxaliplatin has shown efficacy in patients with platinum-pretreated ovarian cancer and achieved objective response rates similar to paclitaxel in this setting ( 16 vs 17 % ) .
promising results have also been found with oxaliplatin in patients with non-hodgkin 's lymphoma , breast cancer , mesothelioma and non-small cell lung cancer .
conclusion : oxaliplatin in combination with fluorouracil/folinic acid is an effective treatment option for patients with metastatic colorectal cancer , both as a first-line therapy and in patients refractory to previous chemotherapy .
additional clinical investigation of oxaliplatin in patients with other cancers is warranted given the promising results achieved in early trials , most notably in patients with platinum-pretreated ovarian cancer .
combined modality treatment has 'come out of age ' and increasingly represents standard of care for a rapidly growing number of patients in locally advanced stages of nsclc .
the current study was designed to assess the prognostic value of immunomorphologic changes in locoregional lymph nodes and lymphocytic infiltration of primary tumor ( li ) in patients who undergo resection for bronchogenic carcinoma .
conclusions : lymph node immunoreactivity and li significantly influence long term survival after curative surgery for patients with carcinoma of the lung and may be useful in stratifying patients for prospective trials of adjuvant treatment , including immunotherapy .
the drug is currently in phase iii clinical trials for patients with non-small cell lung cancer in combination with paclitaxel and carboplatin , as well as in advanced hormone refractory prostate cancer in combination with mitoxantrone .
standard treatment of sclc consists of platinum-based combination chemotherapy , with thoracic irradiation added for patients with limited-stage disease .
several newer chemotherapeutic drugs have recently been shown to have significant activity in patients with untreated or relapsed sclc .
we recently performed completion pneumonectomy of the left lung in a 70-year-old man with hemophilia a , for squamous cell carcinoma in the residual left lung .
objective : several reports emphasize the importance of en-bloc resection as the optimal surgical treatment of lung cancer with chest wall invasion .
methods : between 1981 and 1998 , 100 patients ( 90 male ; ten female ) , with a median age of 60 years ( 36-84 ) , underwent radical en-bloc resection of non-small cell lung cancer ( nsclc ) with chest wall involvement .
over the past 17 years ( 1981 to 1997 ) , 29 patients underwent complete pulmonary resection for primary lung cancer accompanied by satellite nodules in the same lobe as the primary .
of 1 , 042 patients with primary lung cancer who underwent resection from 1982 to 1995 , 549 patients with adenocarcinoma ( ad ) and 363 with squamous cell carcinoma ( sq ) were included in this study .
for small cell lung cancer ( sclc ) , which accounts for approximately 20 % of cases of lung cancer , the primary treatment is chemotherapy and in the majority of cases the primary aim is to control the disease which generally would have spread beyond the lungs at the time of presentation .
as a best-case scenario , postoperative irradiation may improve the chance for long-term survival in patients with n2 tumors .
for patients with stage i or ii non-small cell lung cancer ( nsclc ) , surgical resection is considered the standard of care .
efforts at improving survival for early-stage nsclc patients have focused on the use of chemotherapy administered postoperatively ( adjuvant ) or preoperatively ( neoadjuvant or induction ) to eradicate micrometastatic disease .
chemotherapy administered before surgery or definitive irradiation has improved survival rates in patients with stage iii nsclc .
patients : patients with a single ( n = 2 , 764 ) and synchronous nsclc ( n = 85 ) who underwent pulmonary resection .
background : prophylactic cranial irradiation halves the rate of brain metastases in patients with small cell lung cancer .
objectives : this study aims to test whether prophylactic cranial irradiation prolongs survival of patients with small cell lung cancer in complete remission .
reviewer 's conclusions : prophylactic cranial irradiation significantly improves survival and disease-free survival for patients with small cell lung cancer in complete remission .
methods : non-small cell lung cancer cells were treated with gemcitabine , harvested , and nuclear extracts analyzed for nf-kappab dna binding by electrophoretic mobility shift assays .
novel treatment strategies for patients with advanced nsclc may involve chemotherapy combined with inhibition of nf-kappab-dependent cell-survival pathways .
combination chemotherapy is the cornerstone of treatment that confers a meaningful survival benefit for patients with small-cell lung cancer .
in single-agent phase ii studies , irinotecan yielded response rates between 16 % and 47 % in patients with previously treated small-cell lung cancer .
a phase ii study of irinotecan in combination with cisplatin ( platinol ) resulted in a response rate of 86 % and a median survival of 13.0 months in patients with extensive-disease small-cell lung cancer .
based on these results , the irinotecan and cisplatin combination is a new standard regimen in the treatment of extensive-disease small-cell lung cancer .
background : both gemcitabine and etoposide are active in the treatment of small-cell lung cancer ( sclc ) , and are characterised by mild toxicity profiles .
patients and methods : forty-two chemo-naive extensive disease sclc patients were enrolled to receive gemcitabine 1000 mg/m2 , days 1 , 8 and 15 , and etoposide 80 mg/m2 , days 8 , 9 and 10 of a 28-day cycle .
background : to find the maximum tolerated dose for ifosfamide in combination with paclitaxel and carboplatin in small-cell lung cancer patients ( sclc ) , who are resistant to cyclophosphamide , doxorubicin and etoposide ( cde ) .
conclusions : the maximum tolerated dose of this combination for patients with resistant sclc is ifosfamide 2000 mg/m2 in combination with paclitaxel 175 mg/m2 and carboplatin auc 6 mg/ml min administered on the first day of a 21-day cycle .
many endobronchial treatment modalities are available to supplement traditional therapies for advanced lung cancer .
methods : the author reviews the use of several endobronchial treatment modalities that can augment standard antitumor therapies for advanced lung cancer , including rigid and flexible bronchoscopy , laser therapy , endobronchial prosthesis , and photodynamic therapy .
conclusions : endobronchial interventions are important adjuncts in the multimodality management of lung cancer and should become standard considerations in the management of patients with advanced lung cancer .
standard operations for lung cancer patients are generally accepted as performing lobectomy or pneumonectomy on the tumor baring lung and ipsilateral hilar and mediastinal lymphadenectomy including subcarinal lymph nodes .
small cell lung cancer is a frequently relapsing tumor despite a high rate of response after first-line chemotherapy .
for symptomatic metastases in bone or brain , radiotherapy usually gives temporary palliation .
for intrathoracic relapse and severe obstruction of main bronchus and/or superior caval vein , radiotherapy is a possibility if not given as part of first-line treatment .
an anti-idiotypic monoclonal antibody against the gd3 ganglioside , bec-2 , is being evaluated after chemotherapy in sclc patients in a european study .
the matrix metalloproteinase inhibitors marimastat and bms-275291 are under evaluation in sclc .
we attempted a new regimen of intermittent administration of 5-fu and low-dose isovorin ( f.i ) to four patients with advanced and recurrent colon cancer .
purpose/objectives : to describe the relationship between fatigue and nutritional status in patients receiving radiation therapy for lung cancer .
sample : 45 adults with primary cancer of the lung receiving < outpatient primary or adjuvant radiation therapy .
we present the case of a patient with metastatic transitional cell carcinoma of the bladder and renal failure who underwent successful systemic chemotherapy with paclitaxel and carboplatin .
background : the objective of this phase ii study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma ( nsclc ) by the administration of carboplatin plus gemcitabine followed by of paclitaxel .
conclusions : this study is the first to evaluate planned sequential chemotherapy in patients with nsclc .
patients who benefit from a surgical resection for non-small-cell lung cancer with aneuploid dna content prove to have a higher risk of death .
purpose : this randomized trial was designed to determine whether paclitaxel plus carboplatin ( pc ) offered a survival advantage over vinorelbine plus cisplatin ( vc ) for patients with advanced non -- small-cell lung cancer .
conclusion : pc is equally efficacious as vc for the treatment of advanced non -- small-cell lung cancer .
purpose : a prospective randomized trial in small-cell lung cancer ( sclc ) was performed to determine if intensification of the platinum dose by giving cisplatin and carboplatin in combination to patients with sclc yields higher response rates and survival , than carboplatin alone in a combination chemotherapy regimen .
conclusions : the intensification of platinum dose ( cisplatin plus carboplatin ) in combination chemotherapy significantly increased the complete response rate , overall survival and number of two-year survivors among sclc patients with limited disease compared to combination therapy with carboplatin alone , suggesting that a more aggressive treatment to this category of patients is worthwhile , while no difference in treatment outcome was observed for patients with extensive disease .
the aim of this study was to investigate the relationships among technetium-99m tetrofosmin ( tc-tf ) accumulation in untreated small cell lung cancer ( sclc ) , the expression of p-glycoprotein ( pgp ) and multidrug resistance related protein-1 ( mrp1 ) , and the response to chemotherapy in patients with untreated sclc .
tc-tf chest scintigraphy correlated well with pgp or mrp1 expression and accurately predicted the response to chemotherapy in patients with sclc .
exploratory interventions , partial tumor resections and lung resections for metastasis were more frequently performed in young patients than in older patients .
in the present report , we reviewed articles on pulmonary angiography for patients with pulmonary hypertension .
prophylactic cranial irradiation ( pci ) has been demonstrated to significantly reduce the incidence of brain relapse from limited disease small-cell lung cancer ( ld sclc ) , but concerns about neurologic toxicity remain .
thus , twice-daily pci should be considered for patients with ld sclc who achieve a complete response to chemoirradiation .
animal studies suggest that the kidney is involved in the elimination of recombinant human granulocyte colony-stimulating factor ( rhg-csf ) , which is used for patients with neutropenia during cancer chemotherapy .
in a pivotal phase iii trial , 242 patients with advanced ovarian cancer were randomised to receive treatment with cisplatin 100 mg/m2 and cyclophosphamide 1000 mg/m2 every 3 weeks with or without pretreatment with intravenous amifostine 910 mg/m2 .
over 6 cycles of therapy , amifostine significantly reduced haematological , renal and neurological toxicities : treatment delays , treatment discontinuation and days in hospital related to these adverse events were also significantly reduced in patients receiving amifostine versus patients receiving chemotherapy alone .
amifostine ( 340 mg/m2 ) also provided significant protection against pneumonitis and oesophagitis in patients with lung cancer receiving thoracic irradiation in a preliminary report from a phase iii trial ( n = 144 ) .
amifostine has also been shown to stimulate haematopoietic stem cells and has been investigated as a therapy for patients with myelodysplastic syndrome in number of small preliminary studies .
depending on the outcome of numerous ongoing clinical trials , amifostine may eventually find broader clinical applications , both as a cytoprotectant and as a potential therapy in myelodysplastic syndrome .
to perform a curative operation for the lung cancer without myocardial infarction , minimally invasive direct coronary artery bypass and left lower lobectomy with video-endoscopic assistance were performed simultaneously .
A review of the fetal-maternal carboxyhemoglobin relationships and the differences in fetal oxyhemoglobin physiology are used to explain the recommendation that pregnant women with carbon monoxide poisoning should receive 100 % oxygen therapy for up to five times longer than is otherwise necessary .
The authors describe the case of a child with status epilepticus in whom phenytoin was administered via the intraosseous route , and seizure resolution and therapeutic serum levels were achieved .
A patient suffering baclofen overdose successfully treated with atropine is reported .
Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension .
Therapeutic effect of a left ventricular assist device on acute myocardial infarction evaluated by magnetic resonance imaging .
Continuous arteriovenous hemofiltration for the treatment of anasarca and acute renal failure in severely burned patients .
Continuous renal replacement therapy in patients with acute renal dysfunction undergoing intraaortic balloon pump and/or left ventricular device support .
Continuous arterio-venous hemofiltration in a wearable device to treat end-stage renal disease .
The effectiveness of neostigmine 0.07 mg kg-1 and edrophonium 0.8 mg kg-1 as antagonists of profound neuromuscular blockade induced by vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1 was studied in 59 healthy patients .
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium has been studied using the tetanic ( 50 Hz ) and train-of-four ( 2 Hz ) or single twitch responses of the adductor pollicis muscle in 22 anaesthetized patients .
Active forms of vitamin D3 , 1 alpha-hydroxyvitamin D3 and 1 alpha , 25-dihydroxyvitamin D3 , were administered in an open-design study to 40 patients with psoriasis vulgaris in three ways : to 17 patients 1 alpha-hydroxyvitamin D3 was given orally at a dose of 1.0 micrograms/day for 6 months , to four patients 1 alpha , 25-dihydroxyvitamin D3 was given orally at a dose of 0.5 microgram/day for 6 months , and 19 patients were given 1 alpha , 25-dihydroxyvitamin D3 applied topically at concentration of 0.5 microgram/g of base for 8 weeks .
These data suggest that psoriasis may respond to active metabolites of vitamin D3 and that abnormalities in vitamin D metabolism or in responsiveness of the skin cells to active metabolites of vitamin D may be involved in the pathogenesis of this skin disease .
Successful treatment of psoriasis with topical application of active vitamin D3 analogue , 1 alpha , 24-dihydroxycholecalciferol .
We suggest that 1 alpha , 24 ( OH ) 2D3 merits further investigation as a potentially useful topical therapy for psoriasis .
When indomethacin was applied immediately after irradiation , UVR ( ultraviolet radiation ) dose-dependent suppression of erythema was demonstrated for both wavelengths until 36 h after irradiation when both indomethacin and control gel base-treated sites were equally erythematous .
Suppression of erythema also occurred when application of indomethacin was delayed until 24 h after irradiation , showing that for both wavelengths prostaglandin synthesis remains increased throughout this period .
There was one retinal dialysis , and one lens dislocation requiring extraction .
Rates of superoxide ( SA ) generation by blood monocytes stimulated ex vivo were studied before and during corticosteroid treatment of rheumatoid arthritis ( RA ) patients , in control patients and in healthy controls .
Significant inhibition of monocyte SA output stimulated with IgG-treated zymosan ( ITZ ) and fluoride ion ( F ) , but not serum-treated zymosan ( STZ ) was demonstrated following steroid therapy in RA .
Methotrexate ( MTX ) appears to be useful in patients with rheumatoid arthritis ( RA ) refractory to other drugs but its long-term toxicity and efficacy are uncertain .
MTX in a low-dose regimen is useful in refractory RA and superior to low-dose purine analogues .
Twelve patients with intractable rheumatoid arthritis were treated with antilymphocyte globulin ( ALG ) , prednisolone and a cytotoxic agent , usually azathioprine , and were followed for 1 year .
Rigid ureteroscopy for the treatment of ureteric calculi : experience in 120 cases .
Over a 1-year period , rigid ureteroscopy has been used to retrieve ureteric calculi in 120 patients .
Eleven patients with vesicoureteric reflux secondary to neuropathic bladder were treated by endoscopic injection of pyrolised polytetrafluoroethylene ( Polytef ) paste .
Two hundred and seventy-seven patients with advanced prostatic cancer were treated by either orchiectomy or oestrogen .
Use of scarred flaps and secondary flaps for reconstructive surgery of extensive burns .
A patient with a vesico-enteric fistula was successfully treated with resection of the small intestine and dome of the bladder and drainage of the intervening abscess .
Supramaximal horizontal rectus surgery in the management of third and sixth nerve palsy .
Supramaximal medial and lateral rectus surgery was performed to correct horizontal deviations in seven cases of sixth nerve palsy and three cases of third nerve palsy , with satisfactory results in most cases .
Steroid therapy was also used in two patients with NSAID-induced proteinuria .
Recombinant leukocyte A interferon ( rIFN-alpha A ) in the treatment of disseminated malignant melanoma .
Ninety-six patients with disseminated malignant melanoma received thrice weekly intramuscular injections of leukocyte A recombinant interferon ( rIFN-alpha A , Roferon-A , Hoffmann La Roche ) at doses of 12 X 10 ( 6 ) U/m2 or 50 X 10 ( 6 ) U/m2 with or without cimetidine as an immunorestorative agent .
As noted previously , using chemotherapy , a small proportion of patients with advanced malignant melanoma , despite prior therapy , may achieve prolonged objective regression with rIFN-alpha A .
Clinical course of breast cancer patients with osseous metastasis treated with combination chemotherapy .
Between July 1973 and December 1979 , 1171 patients with metastatic breast cancer were treated with doxorubicin-containing chemotherapy .
Two patients with metastatic dysgerminoma of the ovary were treated with a combination of etoposide , bleomycin , and cisplatin at The University of Texas M.D .
Chemotherapy may be an alternative to radiotherapy for the treatment of metastatic dysgerminoma and should also be considered for selected patients with Stage I disease .
Long-term survival and morbidity in patients with metastatic malignant germ cell tumors treated with cisplatin-based combination chemotherapy .
Treatment of advanced stage mycosis fungoides with bleomycin , doxorubicin , and methotrexate with topical nitrogen mustard ( BAM-M ) .
Ten patients with advanced stage ( TNM IIB-IVB ) mycosis fungoides were treated with a combination chemotherapy program consisting of bleomycin and methotrexate weekly , doxorubicin every 3 weeks , and topical nitrogen mustard daily ( BAM-M ) .
Three patients in whom splenomegaly was detected during their staging evaluation underwent splenectomy .
This study indicates that BAM-M is effective therapy for advanced stage mycosis fungoides and suggests that the therapeutic role of splenectomy should be evaluated further .
Only patients whose primary head and neck tumor shows a response to systemic therapy undergo Ommaya placement .
Additional chemotherapy may thus have eradicated these micrometastases in the older children , since the age influence on Stage II disease disappeared when multimodal treatment was given in this study .
Traditional therapy for malignant pleural effusions includes thoracentesis or tube drainage with instillation of irritants to achieve pleurodesis .
We feel that pleuroperitoneal shunting is a valid new method for treatment of malignant pleural effusions which can effectively palliate respiratory symptoms with low morbidity .
When right ventricular failure prohibits separation from cardiopulmonary bypass , standard methods of increasing pulmonary blood flow should be employed , including correction of hypoxia and acidosis , volume loading , and inotropic support of the right ventricle .
For refractory right ventricular failure following the surgical repair of congenital cardiac defects in which the placement of right atrial and pulmonary artery cannulae is not technically feasible , use of high-frequency high-volume ventilation appears to be quite promising .
Current results suggest that RHBP remains the gold standard for severe RV failure , but further clinical experience with PABC may more clearly define its role in the management of RV failure .
Guiding surgical therapy of ventricular tachycardia by preoperative endocardial catheter mapping necessitates improvement of the accuracy of localization of the arrhythmogenic site .
However , the results of this study indicate that procainamide may be effective in suppressing the induction of sustained ventricular tachycardia at a relatively low plasma concentration , but not at a higher plasma concentration .
Coronary angioplasty for early postinfarction unstable angina .
Coronary angioplasty was performed in 53 patients in whom unstable angina had reoccurred after 48 hr and within 30 days after sustained myocardial infarction .
At 6 months follow-up 26 % ( 14/53 ) of all the patients who underwent angioplasty had recurrence of angina , which was successfully treated with repeat angioplasty , bypass surgery , or medical therapy .
Coronary dissection and total coronary occlusion leading to emergency coronary surgery are the most frequent complications of percutaneous transluminal coronary angioplasty ( PTCA ) and their occurrence usually is unpredictable .
Effect of zanamivir on duration and resolution of influenza symptoms .
A comparison of a five-day regimen of cefdinir with a seven-day regimen of loracarbef for the treatment of acute exacerbations of chronic bronchitis .
Initial empiric therapy for community-acquired bacterial meningitis should be based on the possibility that penicillin-resistant pneumococci may be the etiologic organisms and , hence , should include a combination of third-generation cephalosporin ( cefotaxime or ceftriaxone ) and vancomycin .
Ampicillin should be included if the patient has predisposing factors that are associated with a risk for infection with Listeria monocytogenes .
Results of clinical trials and meta-analysis suggest that dexamethasone therapy improves the outcome for patients with bacterial meningitis .
Placebo-controlled trials have shown that vitamin C supplementation decreases the duration and severity of common cold infections .
Since few trials have examined the effects of therapeutic supplementation and their results have been variable , further therapeutic trials are required to examine the role of vitamin C in the treatment of colds .
Levofloxacin versus intravenous ceftriaxone and amoxicillin/clavulanate in the treatment of community-acquired pneumonia that require hospitalization
Overall 1 year survival ( operative deaths excluded ) was 68 % after tumor resection compared to 31 % after palliative surgery ( P < 0.001 ) .
The results of this study show that resection of extrahepatic bile duct carcinomas , particularly in an upper-third localization , is often associated with worthwhile long-term survival .
Background : N-acetylcysteine ( NAC ) and ambroxol ( AMB ) have recently been proposed as possible therapeutic agents in the treatment of pulmonary disorders .
Antimicrobial therapy for respiratory disease .
Corticosteroids for the treatment of croup .
The PR was observed in one patient with non-functioning endocrine pancreatic tumor with progressive liver and lymph node metastases after 16 months of i.m. lanreotide therapy .
CONCLUSIONS : Octreotide LAR 20 mg shows significant efficacy in terms of objective response rate ( PR + SD ) , biochemical and symptomatic control in patients with metastatic NETs of the GEP system pretreated and progressing on slow release lanreotide .
Inchinko-to ( TJ-135 ) is a herbal medicine consisting of three kinds of crude drugs , and in Japan it is administered mainly to patients with cholestasis .
The present study evaluated the effects of TJ-135 on concanavalin A ( con A ) -induced hepatitis in mice in vivo and con A-induced cytokine production in vitro .
These results suggest that con A-induced hepatitis was ameliorated by pretreatment with TJ-135 .
Therefore administration of TJ-135 may be useful in patients with severe acute hepatitis accompanying cholestasis or in those with autoimmune hepatitis .
Zinc lozenges -- a cure for common colds ?
T-helper type 2 cell-directed therapy for asthma .
Effects of the Japanese herbal medicine 'Inchinko-to ' ( TJ-135 ) on concanavalin A-induced hepatitis in mice .
Presumed cavernomas have been documented following radiation for malignancy ( 5-6 ) , and sterotactic cerebral biopsy ( 7 ) .
Surgical management of syringomyelia associated with spinal adhesive arachnoiditis .
Discontinuation of secondary prophylaxis for cryptococcal meningitis in HIV-infected patients responding to highly active antiretroviral therapy
Hepatectomy for cholangiocarcinoma complicated with right umbilical portion : anomalous configuration of the intrahepatic biliary tree .
Traditionally , the therapy of symptomatic bronchiectasis is based on antibiotics , antibronchoobstructive medication , and chest physical therapy .
Bilateral lung transplantation should be considered in younger patients with severe , generalized bronchiectasis and respiratory failure .
Prospective , randomized , largescale trials supporting any of the different treatment strategies are not available , but antibiotics and surgery probably have improved the long-term outcome of many patients with bronchiectasis .
OBJECTIVES : Interest in zinc as a treatment for the common cold has grown following the recent publication of several controlled trials .
The objective of this review was to assess the effects of zinc lozenges for cold symptoms .
Results from two trials ( 04 - Mossad ; 08 - Smith ) suggested zinc lozenges reduced the severity and duration of cold symptoms .
Given the potential for treatment to produce side effects , the use of zinc lozenges to treat cold symptoms deserves further study .
Randomized trial of interferon-alpha plus ursodeoxycholic acid versus interferon plus placebo in patients with chronic hepatitis C resistant to interferon
We describe a rare case of spontaneous rupture of a hepatic metastasis from renal cell carcinoma that was treated successfully by hepatic arterial embolization .
A 65-year-old woman , who had been undergoing immunotherapy for inoperably disseminated renal carcinoma and lung metastases , presented with severe abdominal pain in a state of hypovolemic shock .
Although hepatic rupture due to metastatic cancer is extremely rare , transcatheter arterial embolization ( TAE ) is an appropriate and useful treatment for massive hemorrhage caused by spontaneous rupture of liver metastasis .
Patients with classical symptoms such as heartburn and regurgitation may be treated pharmaceutically combined with life style counselling .
Surgical treatment is a good alternative for patients with persistent severe regurgitation during medical therapy and for young patients who prefer surgery to lifelong medication .
The surgical treatment of lung lacerations and major bronchial disruptions caused by blunt thoracic trauma .
BACKGROUND : An increasing number of reports indicate symptomatic relief of biliary colic symptoms after cholecystectomy for biliary dyskinesia .
Despite this , cholecystectomy as a treatment for biliary dyskinesia remains controversial .
Our aim was to determine efficacy of cholecystectomy in alleviating biliary dyskinesia symptoms and the correlation with histologic findings .
CONCLUSIONS : Biliary dyskinesia patients who underwent cholecystectomy had significantly greater symptom improvement compared with nonsurgical patients .
Cholecystectomy should be a first-line therapy for biliary dyskinesia patients .
Transbronchial biopsy revealed inflammatory nonspecific alveolar lesions suggestive of bronchiolitis obliterans organizing pneumonia , which responded well clinically and radiologically to oral corticosteroids .
Novel treatment strategies for patients with advanced NSCLC may involve chemotherapy combined with inhibition of NF-kappaB-dependent cell-survival pathways .
Effectiveness of pseudoephedrine plus acetaminophen for treatment of symptoms attributed to the paranasal sinuses associated with the common cold
OBJECTIVE : This retrospective study was designed to confirm that aggressive pulmonary resection can provide effective long-term palliation of disease for patients with pulmonary aspergilloma .
METHODS AND RESULTS : From 1959 to 1998 , 84 patients underwent a total of 90 operations for treatment of pulmonary aspergilloma in the Marie-Lannelongue Hospital .
The lesion was resected by video-assisted thoracoscopic surgery because it was suspected of being a lung abscess that had caused repeated episodes of inflammation .
In this study , we investigated the expression and therapeutic potential of TRAIL in cholangiocarcinoma , one of the most devastating human hepatic malignancies .
Finally , in vivo administration of recombinant TRAIL substantially inhibited subcutaneous tumor growth of human cholangiocarcinoma cells .
Induction of apoptosis in tumor cells is possible with a biologically active TRAIL , and suggests that this cytokine is a promising antitumor agent against human cholangiocarcinoma .
Interferon plays a critical role in the host 's natural defense against viral infections and in their treatment .
This study investigated whether intensive chemotherapy might have a positive effect on asthma in these special cases and whether asthma generally relapses after completion of chemotherapy .
The authors monitored clinical outcome and lung function of 43 children with acute lymphoblastic leukemia and non-Hodgkin lymphoma who received chemotherapy at the University Children 's Hospital of Greifswald between 1993 and 1998 .
She was diagnosed as miliary tuberculosis and treated with antituberculous drugs .
The hemorrhage was successfully stopped by microcoil embolization .
Immunomodulatory effects of acupuncture in the treatment of allergic asthma : a randomized controlled study .
An open-label study of lamivudine for chronic hepatitis B in six patients with chronic renal failure before and after kidney transplantation .
CONCLUSION : The WDTA is an intrinsically motivating educational program that has the ability to effect determinants of asthma self-management behavior in 9- to 13-year-old children with asthma .
Usefulness of percutaneous transhepatic biliary drainage in patients with surgical jaundice -- a prospective randomised study .
Neutralization of hepatitis A virus ( HAV ) by an immunoadhesin containing the cysteine-rich region of HAV cellular receptor-1
To ascertain the results of standard ABVD chemotherapy ( doxorubicin , bleomycin , vinblastine , dacarbazine ) in HIV-infected patients with newly diagnosed Hodgkin 's disease ( HD ) , a nonrandomized , prospective , multiinstitutional clinical trial was conducted by the AIDS Clinical Trials Group ( ACTG ) , in HIV-infected patients with Hodgkin 's disease .
The effectiveness of glucocorticoids in treating croup : meta-analysis ( see comments )
PURPOSE : Inhaled corticosteroids have beneficial effects on pulmonary function and inflammation in patients with asthma , but they also cause systemic adverse effects , such as adrenal suppression .
Effectiveness of casein hydrolysate feedings in infants with colic ( see comments )
We conclude that antimicrobial/ antituberculous agents have only a minor short-term effect in long-lasting CGM of undetermined cause .
Thus , s-ECP appears to be a useful marker for determining when a step-down in iBDP therapy is indicated , and thus may contribute to successful long-term management of chronic asthma .
AIM : To assess the impact on community-based pediatricians of the conclusions of the 10th Conference de Consensus en Therapeutique Anti-Infectieuse ( CCTAI ) on the antibiotic treatment in acute nasopharyngitis ( ANP ) .
We assessed the prevalence of head louse infestation and the effectiveness of 1 % permethrin against head lice in Kosovar refugees .
Refugees with crawling lice were treated with a pediculicide containing 1 % permethrin .
We conclude that 1 % permethrin treatment was effective in louse control in this refugee population .
Antibiotics for Salmonella meningitis in children .
Four patients developed mild pancreatitis , one had moderate pancreatitis and one had leak of contrast , which was treated by administration of clear fluids orally for one day .
We treated two children with influenza-associated acute encephalopathy by a combination of mild hypothermia and steroid pulse therapy .
Successful treatment of anaerobic pleuropulmonary infections requires a combination of antibiotic therapy and surgical interventions .
Treatment of spontaneous carotid-cavernous fistula in Ehlers-Danlos syndrome by transvenous occlusion with Guglielmi detachable coils .
PURPOSE : Macrolide antibiotics are frequently prescribed to patients with symptoms of a common cold .
Because the symptoms of rhinovirus colds are attributed to the inflammatory response to infection , we studied the effects of treatment with clarithromycin on the symptomatic and inflammatory response to nasal inoculation with rhinovirus .
Therapeutic pneumothorax ( TP ) proved its efficacy in pre-antibiotic era , so one can assume that it can be applied with the same success in multidrug resistant TB .
In conclusion , in some cases of MDR TB , the TP ( if there are no pleural adherences ) may lead to good results .
Acupuncture treatment of common cold
When bleeding is stopped via surgical or radiological methods , the clinical course of hemobilia-associated pancreatitis appears to be benign .
A case of biliary stenosis in polycystic liver improved by injection of minocycline hydrochloride to a hepatic cyst
The ruptured horn was excised by laparotomy .
Therapy designed to control the efferent phase of established asthma by augmenting down-regulatory Th1 counterbalancing mechanisms should be effective .
All children with croup symptoms who demonstrate increased work of breathing in the clinics or emergency departments should be treated with glucocorticoids .
Increasing resistance among the common respiratory pathogens has encouraged assessment of alternative agents , for example , levofloxacin .
Unlike earlier quinolones , levofloxacin has excellent activity against Streptococcus pneumoniae , including strains resistant to penicillin .
Clinical trials show levofloxacin to be as effective as cephalosporins in acute exacerbation of chronic bronchitis and as effective as co-amoxiclav , cephalosporins or amoxycillin in community-acquired pneumonia .
Additionally , epidemiologic evidence of a marked decline in new KS since the widespread use of highly active antiretroviral therapy ( HAART ) advocates its use .
Gingyo-san and its components were administered orally to mice 1 day before , then 1 and 4 days after the inhalation of a mouse-adopted strain of influenza A2 ( H2N2 ) virus .
From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A2 virus .
The purpose of the present study was to analyze the association of recurrent abdominal pain and H. pylori infection in children and to evaluate the efficacy of antimicrobial treatment in patients with evidence of infection .
Patients with evidence of infection with H. pylori were treated with a combination of omeprazole , amoxicillin , and clarithromycin .
Treatment with omeprazole , amoxicillin , and clarithromycin resulted in eradication of the infection in all and in resolution of the clinical symptoms in 15 ( 80 % ) of 19 patients who had a follow-up examination .
A combined therapy results in eradication of the bacterium and in improvement of the clinical symptoms in a significant majority of the patients .
In certain clinical settings , interventional radiologic procedures have become an important alternative to surgery in the treatment of gallstones and their complications ; techniques include percutaneous cholecystostomy and gallstone removal .
BACKGROUND : The administration of salbutamol is permitted only by inhalation by the International Olympic Committee ( IOC ) for the management of asthma and exercise-induced asthma in athletes .
Urine was also obtained from subjects who had received the maximum dosage of inhaled salbutamol advisable for competing athletes to provide protection from exercise-induced asthma and treatment of asthma ( 1600 microg in 24 h , 800 microg being in the last 4 h ) .
Antimicrobials were prescribed to 175 ( 83.73 per cent ) patients with common cold and 78 ( 82.11 per cent ) patients with diarrhea .
OBJECTIVE : to evaluate the possible existence of the so-called < Roux-en-Y syndrome > in a group of 21 patients who underwent surgery to correct postoperative alkaline reflux gastritis .
All had undergone Billroth II subtotal gastrectomy ( 20 for ulcer and 1 for gastric cancer ) .
CONCLUSIONS : we found no evidence of disturbances in gastric remnant emptying after Roux-en-Y gastrojejunostomy to treat postoperative alkaline gastric reflux .
BACKGROUND : Drainage methods for the gastric conduit after esophagectomy for carcinoma have been controversial .
Contemporary asthma management guidelines list inhaled corticosteroids as the preferred controller medication for patients with persistent asthma .
Fluticasone propionate is one of several inhaled corticosteroids used for the treatment of asthma .
A series of comparative analyses show that inhaled fluticasone propionate is more cost effective than oral zafirlukast and triamcinolone acetonide and slightly more cost effective than flunisolide in adult patients with asthma .
Quality-of-life assessments in patients with mild to moderate disease show that inhaled fluticasone propionate achieved improvements which were deemed to be clinically meaningful in patients with mild to moderate asthma ; these changes were significantly greater than those achieved with oral zafirlukast , inhaled triamcinolone acetonide or placebo .
CONCLUSIONS : In addition to the considerable body of clinical evidence supporting the use of inhaled fluticasone propionate in patients with asthma , accumulating short term cost-effectiveness data also suggest that this agent can be administered for a similar or lower cost per outcome than other inhaled corticosteroids or oral zafirlukast .
Importantly , the clinical benefits offered by fluticasone propionate in patients with persistent asthma are accompanied by clinically significant improvements in quality of life .
Combination therapy with interferon-alpha ( IFN alpha ) plus Ribavirin has been shown to improve the response rate in patients with chronic hepatitis C as compared to IFN alpha alone .
To prove , whether Ribavirin has any additional effect on the decline of hepatitis C viremia during the first weeks of treatment patients with and without combination therapy were compared .
In patients with combination therapy , a further reduction of viremia level could be observed , whereas viremia levels in patients with IFN alpha alone slightly increased .
Ribavirin in combination with IFN alpha exerts an additional anti-viral/immunmodulatory effect which manifests itself in phase 2 of hepatitis C viremia decline .
Surgical clearance of CBD stones was achieved in 58 patients ( 93.5 % ; group Ia ) .
Use of ES to treat CBD stones on a routine basis was therefore not found to be any better than one-time surgical exploration .
Effect of cholecystectomy on gastroesophageal and duodenogastric reflux
It is suggested that damaged mucosal tissues with AHF can be effectively compensated by enhanced regeneration response due to an adequately high dose intensity , suggesting a possible tolerability advantage for AHF .
Minimally invasive treatment of abscesses by CT-controlled drainage with a basket catheter system
PL granule is one of the most common forms of composite medicine for colds in Japan , including acetaminophen .
A 72-year old man who had been prescribed amiodarone for more than one year before for arrhythmogenic right ventricular dystrophy , repeatedly took PL granules at one-week intervals because of sneezing and fever .
He needed mechanical ventilation for severe hypoxemia , but recovered with glucocorticoid pulse therapy .
In a follow-up study operative risk , postoperative functional disorders and incidence of anastomotic ( recurrent ) ulcer after partial gastrectomy with Roux-en-Y gastrojejunostomy for gastroduodenal ulcer were evaluated in 52 patients .
OBJECTIVE : The aim of these studies was to compare the pharmacokinetics of inhaled fluticasone propionate ( FP ) after repeated administration via the Diskus or Diskhaler dry powder inhalers ( DPIs ) to patients with mild-to-moderate asthma .
CONCLUSION : In patients with asthma receiving repeated inhaled doses of FP , the systemic exposure ( AUC ) after inhalation from the Diskus was similar to that from the Diskhaler , with no difference between the DPIs in the effects on cortisol suppression .
DATA SYNTHESIS : Recently , an expert panel of the Centers for Disease Control and Prevention recommended use of only three of 16 systemic antibiotics approved by the Food and Drug Administration for treatment of AOM : amoxicillin , cefuroxime axetil , and ceftriaxone .
A three-step treatment algorithm for refractory AOM that employs amoxicillin , trimethoprim/sulfamethoxazole ( TMP/SMX ) , or high-dose amoxicillin/clavulanate ( depending on the prior dose of and adherence to amoxicillin therapy ) , and ceftriaxone or tympanocentesis at steps 1 , 2 , and 3 , respectively , appears rational and cost-effective .
CONCLUSIONS : Amoxicillin remains the antibiotic of choice for initial empiric treatment of AOM , although the traditional dosage should be increased in patients at risk for drug-resistant S. pneumoniae .
This model can be used to test the safety and efficacy of liver-assist devices aimed at temporizing the detoxification functions of the failing liver .
dverse outcomes and opioid analgesic administration in acute abdominal pain
We examined the remnant stomach for H. pylori infection after gastrectomy for gastric cancer or peptic ulcer between October 1992 and July 1997 .
The recent introduction of ribavirin , given in combination , has led to a re-appraisal of the management of chronic hepatitis C .
The current report considers the additional benefit of combination therapy ( interferon alfa and ribavirin ) compared with monotherapy ( interferon alfa alone ) for the treatment of patients with chronic hepatitis C .
OBJECTIVE : To review the clinical effectiveness and cost-effectiveness of combination therapy with interferon alfa and ribavirin in patients with chronic hepatitis C .
Sida cordifolia L. ( Malvaceae ) is used in folk medicine for the treatment of inflammation of the oral mucosa , blenorrhea , asthmatic bronchitis and nasal congestion .
Double-blind placebo-controlled trial of Mycobacterium vaccae immunotherapy for tuberculosis in KwaZulu , South Africa , 1991-97 .
OBJECTIVE : To evaluate the efficacy of oral tacrolimus as an induction agent in steroid-refractory severe colitis .Study design : Open-label , multicenter trial of oral tacrolimus in patients with severe colitis .
CONCLUSION : Although tacrolimus is effective induction therapy for severe ulcerative or Crohn 's colitis , fewer than 50 % of patients treated will successfully achieve a long-term remission .
Cytomegalovirus ( CMV ) infection was one of the most common opportunistic infections in AIDS patients , leading to blindness or life-threatening disease in about 40 % of patients in the later stages of AIDS before highly active antiretroviral therapy ( HAART ) .
The study involved 117 infants ( mean age 2.6 months ) , who needed hospital treatment because of RSV bronchiolitis .
According to the present study it seems that inhaled corticosteroid treatment during and after the acute phase of infant RSV bronchiolitis may have a beneficial effect on subsequent bronchial wheezing tendency .
OBJECTIVE : This study was designed to evaluate the safety and estimate the efficacy of oral budesonide in patients with primary sclerosing cholangitis ( PSC ) .
Combined interferon and lamivudine therapy : is this the treatment of choice for patients with chronic hepatitis B virus infection ?
She had been taking amitriptyline 75 mg at night for depression for four months before her admission .
We assessed the effects of early replacement therapy with protein-C concentrate together with continuous veno-venous haemodiafiltration and conventional treatment in meningococcaemia .
The purpose of this study was to determine if topical DL-alpha-tocopherol ( vitamin E ) could reduce ultraviolet-induced damage to the epidermis .
We observed the effects of cisapride in the management of idiopathic constipation in children .
METHODS : Thirty-seven children with a history of constipation ( i.e. , pain and difficulty or delay in defecation for > 3 months ) were recruited and randomly assigned to 8 weeks of treatment with either cisapride , 0.2 mg/kg three times daily , or matching placebo after a 2-week run-in period in a double-blind , parallel-group study design .
Patient 1 demonstrated dramatic clearing of his MCV lesions when intravenous cidofovir therapy was started for his treatment-resistant bilateral CMV retinitis and because of cidofovir 's possible activity against MCV .
In case 2 , cidofovir was compounded as a 3 % cream in a combination vehicle ( Dermovan ) for extensive facial involvement , and complete resolution of MCV was seen after 1 month of therapy .
In case 3 , intravenous cidofovir therapy was started both for CMV retinitis and in an attempt to clear 90 % facial MCV involvement ; after 1 month of treatment , all clinical evidence of MCV had resolved .
CONCLUSIONS : Cidofovir , a nucleotide analog of deoxycytidine monophosphate , appears to have contributed to clearing of advanced MCV lesions in these 3 patients , thus providing suggestive evidence of clinical activity against MCV .
Controlled trials of cidofovir therapy for MCV in persons infected with human immunodeficiency virus are warranted .
OBJECTIVE : This study aimed to determine the effect of external beam radiation therapy on choroidal neovascularization ( CNV ) secondary to age-related macular degeneration ( AMD ) .
Thrombolytic therapy has been accepted in the treatment of acute myocardial infarction .
A bolus infusion of tissue plasminogen activator was administered during CPR in refractory ventricular fibrillation ( two cases ) and pulseless ventricular tachycardia ( one case ) .
We conclude that bolus thrombolytic infusions during CPR may facilitate spontaneous return of circulation in select patients with confirmed acute myocardial infarction , witnessed cardiac arrest in the ED , and refractory ventricular fibrillation or tachycardia .
Touch sensibility was assessed with von Frey 's monofilaments in the breasts of 10 healthy women ( controls ) and of 80 women with breast cancer who at least 1 year previously had undergone subcutaneous mastectomy and immediate reconstruction with a prosthesis .
Local injection of corticosteroids into refractory esophageal strictures to decrease the restenosis rate has been reported .
We systematically reviewed the evidence concerning the ability of five systemic treatments to induce remission in patients with severe psoriasis : ultraviolet B ( UVB ) , photochemotherapy ( PUVA ) , methotrexate ( MTX ) , retinoids ( RET ) and cyclosporin A ( CYA ) .
Consequently , parenteral nutrition ( PN ) solutions used to treat malnourished patients with chronic renal failure usually are prepared with little supplementation of these cations .
PURPOSE : We report a multicenter experience using tubularized incised plate urethroplastym for proximal hypospadias .
MATERIALS AND METHODS : From August 1993 to December 1996 tubularized incised plate urethroplasty was performed in 27 boys 6 months to 3 years old with mid shaft and penoscrotal hypospadias .
RESULTS : Tubularized incised plate surgery created a functional neourethra even in penoscrotal hypospadias .
CONCLUSIONS : Tubularized incised plate urethroplasty is a versatile operation that corrects proximal hypospadias defects with few complications and superior cosmetic results .
Aortocoronary bypass grafting is an accepted procedure for ischemic heart disease .
Immunotherapy of mice with preexisting cancers with heat shock protein preparations derived from autologous cancer resulted in retarded progression of the primary cancer , a reduced metastatic load , and prolongation of life-span .
We describe such an event in a man who underwent allogeneic BMT for APL in second relapse and 4 years later presented with testicular relapse .
Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients .
After a 2- to 9-day placebo lead-in , 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks .
Fludarabine and ara-C successfully eradicated bone marrow disease in 16 of 27 patients ( 59 % ) , 23 patients of which had been treated previously with high-dose ara-C .
These results verified the synergistic effect fludarabine exhibited in augmenting ara-CTP concentrations in patients ' leukemic blasts , thus improving the clinical response in relapsed pediatric leukemias .
BACKGROUND : The growing use of heparin in acute thrombotic disorders , coupled with the availability of many new antithrombotic agents , emphasizes the need for adequate characterization of the platelet effects of the various anticoagulants .
METHODS AND RESULTS : Platelet P-selectin ( CD62 ) and activated GP IIb/IIIa ( PAC-1 ) expression on platelet membrane was quantified in whole blood as well as platelet aggregation in platelet-rich plasma in 43 patients with unstable angina before and during treatment with UFH or enoxaparin .
PURPOSE : We review our initial experience with direct percutaneous transluminal angioplasty ( PTA ) as a reperfusion treatment for acute occlusion of the middle cerebral artery .
Women randomised to screen-and-treat received appropriate antibiotics only if screening proved positive for one or more infection .
We advise that lamivudine should be considered during intensive chemotherapy treatment of chronic carriers of HBV .
OBJECTIVES : The purpose of this analysis was to determine the influence of an additional treatment delay inherent in transfer to an angioplasty center for primary angioplasty of patients with acute myocardial infarction who are first admitted to hospitals without angioplasty facilities .
BACKGROUND : Several randomized trials have demonstrated the benefits of primary angioplasty in acute myocardial infarction .
We report the first case ( to our knowledge ) of an endoscopic removal of a forehead soft tissue mass .
As the overview shows , both groups of substances are useful for individualized treatment of benign prostatic hyperplasia ( BPH ) , provided that conservative pharmacological treatment of BPH is basically accepted and that the patients ' quality of life is also considered .
The results of several clinical investigations showed the efficacy and safety of artichoke extracts ( Cynara scolymus L. ) in the treatment of hepato-biliary dysfunction and digestive complaints , such as sensation of fullness , loss of appetite , nausea and abdominal pain .
Besides the well-known nonsteroidal antiinflammatory drugs ( NSAID ) for the treatment of rheumatic pain herbal medicine can also be applied successfully .
Extracts of the secondary tubers of Devil 's Claw ( Harpagophytum procumbens ) are recommended for the supportive treatment of degenerative painful rheumatism .
High-dose intravenous immunoglobulin ( hdIVIg ) is increasingly used to treat a range of inflammatory and autoimmune diseases .
The current dermatological uses of hdIVIg include the treatment of dermatomyositis and the autoimmune bullous disorders , epidermolysis bullosa acquisita , pemphigoid , and pemphigus .
Unfortunately , current dermatological uses of hdIVIg have been limited to either uncontrolled trials or anecdotal case reports , except for a single controlled trial of hdIVIg as adjunctive therapy in patients with dermatomyositis , which documented a significant benefit .
We describe a technique that enables the autologous repair of large midline incisional hernias by restoring the functional musculoaponeurotic support of the abdominal wall .
OBJECTIVE AND IMPORTANCE : The use of chronic intrathecal morphine for the treatment of intractable , nonmalignant pain is becoming more prevalent .
METHODS : During a 19-month period , seven children with empyema underwent thoracoscopy .
The growing use of automated night-time dialysis ( APD ) in peritoneal dialysis over the last few years shows that this method represents a valid alternative to continuous ambulatory peritoneal dialysis ( CAPD ) .
La Serna et al. ( Lancet 1987 ; 26 : 1517 ) were the first to treat adults with recurrent pericarditis with colchicine , and were followed by other authors .
While these findings are observed for all classes of oral drugs , the issue is especially critical for cancer chemotherapy , in which a narrow therapeutic index is frequently observed .
Treatment for low-grade NHL during the past 30 yr has consisted of high-dose radiation and cytotoxic agents , administered alone or in combination , and high-dose therapy with stem cell transplant .
However , recent clinical use of monoclonal antibodies ( mAbs ) in patients with low-grade or transformed low-grade NHL has resulted in less toxicity than conventional treatments , as well as response rates that are comparable or superior to those achieved with chemotherapy .
Therefore , interest is growing in mAbs as therapeutic alternatives for patients with low-grade NHL and those with transformed histology .
CONCLUSION : The treatment paradigm for NHL is expected to change over the next few years to include radiolabeled mAbs , administered alone or in combination with cytotoxic agents .
RESULTS : Clinical trials of UFT published in the Western world have included 581 patients with colorectal cancer .
The activity of oral UFT in large-bowel cancer when administered with oral LV ( approximately 50 mg/dose ) has resulted in objective response rates of approximately 40 % .
CONCLUSION : UFT is a fluoropyrimidine active in colorectal cancer .
BACKGROUND : Adrenalectomy is the current treatment for phaeochromocytoma .
CONCLUSION : Adrenal-sparing surgery is safe and effective , and may become the treatment of choice in patients with hereditary phaeochromocytoma .
Background : Troglitazone is a new drug for the treatment of type 2 diabetes .
Interferon alfa-2a appears to have antineoplastic efficacy , ( and may have antiretroviral efficacy as well ) in this epidemic neoplasm .
In three consecutive Phase II trials of recombinant interferon alfa-2a ( rIFN alfa-2a ; Roferon-A Hoffmann-La Roche , Nutley , NJ ) involving 96 patients with advanced malignant melanoma , an overall response rate of 22 % was observed .
As single agent therapy in malignant melanoma , interferon alfa-2a was only marginally useful in most patients .
Studies with various interferon alpha preparations , including interferons induced in human leukocytes , interferon alfa-N1 , interferon alfa-2a , and interferon alfa-2b , have all provided evidence for modest but reproducible antitumor activity in advanced renal cell carcinoma .
Preliminary evidence suggests that interferons beta and gamma may also induce regression of metastatic renal cell carcinoma .
The rationale for antileukemic therapy in hairy cell leukemia is to reduce the significant risk of infection and other potential serious complications .
Splenectomy presumably alleviates the pancytopenic effect of hypersplenism by removing the preferred site of leukemic cell proliferation .
Recombinant and natural forms of interferon alpha have been shown to bring about tumor regressions in patients with low-grade non-Hodgkin 's lymphoma .
Current studies using interferon in patients with low-grade non-Hodgkin 's lymphomas are evaluating lower , and perhaps better tolerated doses of interferon .
This approach is being extended to the clinic , and trials are now underway evaluating combinations of interferon and various cytotoxic drugs known from previous studies to be active in patients with low-grade non-Hodgkin 's lymphomas .
While the demonstrated antiviral , antiproliferative , and immunomodulatory properties of interferons have led to a number of theories regarding their potential use in treating individuals with chronic myelogenous leukemia ( CML ) , their limited availability has prevented thorough clinical investigation .
The data resulting from these clinical trials indicate that interferon alfa-2a is effective in inducing hematologic remissions in the majority of minimally treated , benign-phase CML , Ph1-positive patients .
More than 1600 patients with neoplastic disorders have received recombinant human interferon alfa-2a ( Roferon-A , Hoffmann-La Roche , Nutley , NJ ) as part of ongoing or completed clinical trials .
PURPOSE : A phase I/II trial of docetaxel , cisplatin , fluorouracil ( 5-FU ) , and leucovorin ( TPFL5 ) induction chemotherapy for patients with locally advanced squamous cell carcinoma of the head and neck ( SCCHN ) .
PATIENTS AND METHODS : Twenty-three previously untreated patients with stage III or IV SCCHN and Eastern Cooperative Oncology Group functional status less than or equal to 2 were treated with TPFL5 .
Intrathecal sufentanil provides approximately 2 h of excellent labor analgesia with minimal motor blockade .
OBJECTIVE : We report the results of a double-blind , double-dummy , active-control study designed to evaluate the efficacy and safety of lamotrigine ( LTG ) administered as monotherapy to adult outpatients with partial seizures .
BACKGROUND : The effectiveness of LTG as add-on therapy for partial seizures in adults has previously been established .
CONCLUSIONS : We conclude that LTG is effective and well tolerated when administered as monotherapy in adult patients with partial seizures .
BACKGROUND : Omega3 fatty acids may inhibit neuronal signal transduction pathways in a manner similar to that of lithium carbonate and valproate , 2 effective treatments for bipolar disorder .
The present study was performed to examine whether omega3 fatty acids also exhibit mood-stabilizing properties in bipolar disorder .
CONCLUSION : Omega3 fatty acids were well tolerated and improved the short-term course of illness in this preliminary study of patients with bipolar disorder .
Several large-scale trials have firmly established the effectiveness of thrombolytic therapy , beta blockers , and aspirin in the treatment of AMI .
METHODS : Fluvastatin 40 mg daily was administered to 25 patients with hypercholesterolaemia for up to 24 weeks .
Three patients with FAP and two patients with multiple ( more than 30 ) colorectal polyps were administered DHA-concentrated fish oil capsules_Hlk427554600 ( 2.2 g of DHA and 0.6 g of eicosapentanoic acid ( EPA ) per day ) for one or two years .
This article reviews current trends in management of esophageal achalasia , highlighting short-term outcome and cost comparisons of three treatments : botulinum toxin injection , pneumatic dilation , and laparoscopic myotomy .
The clinical application of therapeutic hysteroscopy , mainly in the field of the treatment of abnormal uterine bleeding , started in the 1980s .
Gene therapy of malignant brain tumors
Treatment of irritable bowel syndrome with Chinese herbal medicine : a randomized controlled trial .
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus .
Low-molecular-weight heparin for immediate management of thromboembolic disease in pregnancy .
Tubularized incised plate hypospadias repair for proximal hypospadias .
Comparison of radical prostatectomy and iodine 125 interstitial radiotherapy for the treatment of clinically localized prostate cancer : a 7-year biochemical ( PSA ) progression analysis .
The effectiveness of acupuncture in treating acute dental pain : a systematic review .
Correction of cardiac defects through a right thoracotomy in children .
New technique for mesh repair of paracolostomy hernias .
Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations .
Comprehensive modified diet simplifies nutrition management of adults with short-bowel syndrome .
Extended use of glatiramer acetate ( Copaxone ) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability .
European register of patients with sickle cell disease treated with hydroxyurea is being set up .
Understanding the culture of prescribing : qualitative study of general practitioners ' and patients ' perceptions of antibiotics for sore throats .
Steroid delivery in croup .
Haematoma block versus intravenous regional anaesthesia in Colles ' fractures .
Direct percutaneous transluminal angioplasty for acute middle cerebral artery occlusion .
Magnesium sulphate for the control of spasms in severe tetanus .
Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation : a randomized , controlled study .
Repair of ventral hernias with expanded polytetrafluoroethylene patch .
Spinal manipulation in the treatment of episodic tension-type headache : a randomized controlled trial .
Successful treatment with lamivudine for fulminant reactivated hepatitis B infectioN following intensive therapy for high-grade non-Hodgkin 's lymphoma .
Influence of treatment delay on infarct size and clinical outcome in patients with acute myocardial infarction treated with primary angioplasty .
Should patients with advanced sarcomas be treated with chemotherapy ? .
Plasma exchange and tacrolimus-mycophenolate rescue for acute humoral rejection in kidney transplantation .
Hyperbaric oxygen therapy for children with cerebral palsy .
Endoscopic excision of a forehead mass .
Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line .
Is conservative surgery for tubal pregnancy preferable to salpingectomy ? An economic analysis .
Laparoscopic cornuostomy in the treatment of interstitial pregnancy with subsequent hysterosalpingography .
Experimental evaluation of the use of recombinant prourokinase and its immobilized forms in the treatment of postoperative fibrinoid syndrome in ophthalmology
In vitro and in vivo comparison between the effects of treatment with adenosine triphosphate and treatment with buthionine sulfoximine on chemosensitization and tumour growth of B16 melanoma .
Effects of transpupillary thermotherapy on immunological parameters and apoptosis in a case of primary uveal melanoma .
Is there a rational therapy for symptomatic treatment of benign prostatic hyperplasia with phytogenic drugs ? Illustrated with the example of the prostate agent from Serenoa repens ( Sabal fructus )
Pharmacological and clinical effectiveness of a fixed phytogenic combination trembling poplar ( Populus tremula ) , true goldenrod ( Solidago virgaurea ) and ash ( Fraxinus excelsior ) in mild to moderate rheumatic complaints
Therapy of degenerative diseases of the musculoskeletal system with South African devil 's claw ( Harpagophytum procumbens DC )
Treatment strategy for mucin-producing intrahepatic cholangiocarcinoma : value of percutaneous transhepatic biliary drainage and cholangioscopy .
Strategy for surgical management of ileocolonic anastomotic recurrence in Crohn 's disease .
Nerve-sparing surgery for advanced rectal cancer patients : special reference to Dukes C patients .
Prognostic factors in patients with locally advanced rectal adenocarcinoma treated with preoperative radiotherapy and surgery .
Current surgical therapy for bronchiectasis .
Thoracic surgery for hydatid disease .
Surgical treatment of postpneumonic empyema .
Thoracoscopic surgery for pulmonary tuberculosis .
Thoracoscopic surgery for spontaneous pneumothorax .
Surgery for chronic thromboembolic pulmonary hypertension .
Transabdominal extensive esophagogastric devascularization with gastroesophageal stapling for management of noncirrhotic portal hypertension : long-term results .
Surgical treatment for lung hydatid disease .
Sliding door technique for the repair of midline incisional hernias .
One-lung ventilation in patients with difficult airways .
Thoracoscopy for empyema in children .
Sex differences in the use of asthma drugs : cross sectional study .
Conventional treatments for non-Hodgkin 's lymphoma : the need for new therapies .
Adrenal-sparing surgery for phaeochromocytoma .
Antiplatelet therapy in acute cerebral ischemia .
Laugier-Hunziker syndrome : case report and treatment with the Q-switched Nd-Yag laser .
Thoracoscopic operation for secondary pneumothorax under local and epidural anesthesia in high-risk patients .
Troglitazone-induced hepatic failure leading to liver transplantation .
A modified technique of tubeless anaesthesia for microlaryngoscopy and bronchoscopy in young children with stridor .
A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance .
Treatment of idiopathic thrombopenic purpura in adolescents by intravenous immunoglobulin
Azithromycin therapy for scrub typhus during pregnancy .
Excimer laser assisted in situ keratomileusis for hyperopia .
Three consecutive phase II studies of recombinant interferon alfa-2a in advanced malignant melanoma .
Interferon treatment of renal cell carcinoma .
Current and future uses of recombinant interferon alpha in the treatment of low-grade non-Hodgkin 's lymphoma .
Antimicrobial treatment options in the management of odontogenic infections .
Induction chemotherapy with docetaxel , cisplatin , fluorouracil , and leucovorin for squamous cell carcinoma of the head and neck : a phase I/II trial .
Low-dose steroids reduce flu-like symptoms at the initiation of IFNbeta-1b in relapsing-remitting MS .
Study of three different doses of epidural neostigmine coadministered with lidocaine for postoperative analgesia .
An active-control trial of lamotrigine monotherapy for partial seizures .
Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil , leucovorin , oxaliplatin and surgery .
A simplified laparoscopic technique for mesh placement in ventral hernia repair .
Pharmacological management of acute myocardial infarction .
Mesenteric venous thrombosis : successful treatment by intraarterial lytic therapy .
Gene therapy for myocardial angiogenesis .
Dipyridamole plus aspirin in cerebrovascular disease .
What is the real role of CD40 in cancer immunotherapy ?
Safety and potential effectiveness of daunorubicin-containing liposomes in patients with advanced recurrent malignant CNS tumors .
An experimental application of gene therapy for human retinoblastoma .
Acid suppression therapy in Barrett 's esophagus : the importance of pH monitoring .
Surgical approaches to pediatric defecatory disorders .
Lutein improves visual function in some patients with retinal degeneration : a pilot study via the Internet .
Drug information questions and answers : new for psoriasis : colchicine .
IPPB in severe pulmonary emphysema : limited applications .
Long-term mortality in patients after a British trial of anticoagulants in acute myocardial infarction .
Our results in the surgical treatment of habitual shoulder dislocation with special reference to occupational disability
Alkaline phosphatase in neutrophil leukocytes of patients with infectious mononucleosis and the effect of corticosteroid therapy .
Surgical treatment of uterine cervix insufficiency during the 2d trimester of pregnancy
Physiologic treatment of depressive reactions : a pilot study .
The use of quinidine sulphate for the treatment of atrial fibrillation in twelve horses .
Synergism in the chemotherapy of Eimeria infections of chicks .
Treatment of hydrocele and cysts of the epididymis with sclerosing injections of quinine and urea chlorhydrolactate in a 30 per cent solution
The single-place caisson in the treatment of decompression accidents
Blood volume measurements in burn therapy .
The place of surgery in hypertrophic obstructive cardiomyopathy ( idiopathic hypertrophic subaortic stenosis ) .
The treatment of autoimmune hemolytic anemia with heparin .
Effects of clomiphene citrate on endometrial hyperplasia in the premenopausal female .
Prolonged use of methyldopa in severe hypertension in pregnancy .
Glutathione S-transferase activity in epithelial ovarian cancer : association with response to chemotherapy and disease outcome .
Interferon-alpha-2b in the management of patients with relapsed and/or refractory Hodgkin 's disease .
Thalidomide for aphthous ulcers in HIV infection .
Aspirin therapy in diabetes mellitus .
Combined pancreas-/kidney transplantation as a standard procedure in therapy of kidney failure in type I diabetic patients
Corticosteroid injections for sciatica .
Flutamide plus castration in patients with previously untreated prostate cancer .
The immediate effectiveness of electrical nerve stimulation and electrical muscle stimulation on myofascial trigger points .
In vitro radiation-induced apoptosis and tumour response to radiotherapy : a prospective study in patients with non-Hodgkin lymphomas treated by low-dose irradiation .
Drug therapy for coronary heart disease : the Sheffield table .
Percutaneous drainage of hydatid cysts .
Surgery for ectopia lentis .
High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America .
Is concomitant radiotherapy and chemotherapy superior to optimal radiotherapy alone in anal cancer ?
Standard versus high-dose therapy in 10+ breast cancer .
Anal continence after surgery for rectal prolapse .
Aspirin therapy for cardiovascular disease .
Dosing of amoxicillin/clavulanate for treatment of lower respiratory tract infection .
Pharmacoeconomic analysis of ampicillin-sulbactam versus cefoxitin in the treatment of intraabdominal infections .
New therapies for severe meningococcal disease .
Another potential use of troglitazone in noninsulin-dependent diabetes mellitus .
Evaluation of adjuvant psychological therapy in patients with testicular cancer : randomised controlled trial .
Guidelines for the use of antiretroviral agents in HIV -infected adults and adolescents .
Long-term therapy with long-acting octreotide ( Sandostatin-LAR ) for the management of acromegaly .
Are ABVD and MOPP/ABV truly equivalent for treating Hodgkin 's disease at advanced stages ?
Paclitaxel for the treatment of lymphoma .
Montelukast , a leukotriene-receptor antagonist , for the treatment of mild asthma and exercise-induced bronchoconstriction .
Atypical antipsychotic agents in the treatment of Schizophrenia and other psychiatric disorders .
Percutaneous transluminal angioplasty in the treatment of renovascular hypertension : sequential prospective study .
Esophageal intubation for palliative treatment in advanced carcinoma of the esophagus and cardia
Pathological staging and biochemical recurrence after neoadjuvant androgen deprivation therapy in combination with radical prostatectomy in clinically localized prostate cancer .
How often does surgery for peptic ulceration eradicate Helicobacter pylori ? Systematic review of 36 studies .
A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure .
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major .
Positron emission tomography in assessing response to neoadjuvant chemotherapy for non-small-cell lung cancer .
Reconstruction of thoracic wall defects after tumor resection using a polytetrafluoroethylene soft tissue ( Gore-Tex ) patch .
A comparison of rectal diazepam gel and placebo for acute repetitive seizures .
Effect of long-term salmeterol treatment on exercise-induced asthma .
Randomized trial of intensive cyclophosphamide , epirubicin , and fluorouracil chemotherapy compared with cyclophosphamide , methotrexate , and fluorouracil in premenopausal women with node-positive breast cancer .
Low-molecular-weight heparins in the treatment of venous thromboembolism .
5-year outcome of surgical resection and watchful waiting for men with moderately symptomatic benign prostatic hyperplasia : a Department of Veterans Affairs cooperative study .
For how long should antipsychotic medication be continued after the first psychotic episode in schizophrenics ?
IDA-FLAG ( idarubicin , fludarabine , cytarabine , G-CSF ) , an effective remission-induction therapy for poor-prognosis AML of childhood prior to allogeneic or autologous bone marrow transplantation : experiences of a phase II trial .
Single or double lung transplantation for pulmonary hypertension .
Interferon beta treatment for multiple sclerosis .
Ten-year disease free survival after transperineal sonography-guided iodine-125 brachytherapy with or without 45-Gray external beam irradiation in the treatment of patients with clinically localized , low to high Gleason grade prostate carcinoma .
Partial or near total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia : the pathologist 's role .
Radical prostatectomy for prostate cancer : the perineal approach increases the risk of surgically induced positive margins and capsular incisions .
Open capsulorrhaphy with suture anchors for recurrent anterior dislocation of the shoulder .
Intravenous immunoglobulin treatment in multiple sclerosis .
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer .
The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma .
Perceived contraindications to thrombolytic treatment in acute myocardial infarction .
Lignocaine or bupivacaine for digital ring block .
Steroids in lateral epicondylitis .
Steroids in De Quervain 's tenosynovitis .
Antibiotics after dog bite .
Immobilisation after first anterior shoulder dislocation .
Stereotactic radiosurgery for acoustic neuroma : a Canadian perspective .
Anticytokine therapy -- a new era in the treatment of rheumatoid arthritis ?
Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium .
Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency .
Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson 's disease .
Comparing the efficacy and safety of fluoxetine and venlafaxine in outpatient depression .
Cost-effectiveness of interferon treatment for hepatitis C .
Hyperbaric oxygen therapy for children with cerebral palsy .
Peripheral retinal cryotherapy for postvitrectomy diabetic vitreous hemorrhage in phakic patients .
Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning : a randomised controlled clinical trial .
Multicentre clinical evaluation of vigabatrin ( Sabril ) in mild to moderate partial epilepsies .
Matrix metalloproteinase inhibitors in the treatment of cancer .
High dose cyclophosphamide with carboplatin : a tolerable regimen suitable for dose intensification in children with solid tumors .
Microsurgical treatment of supratentorial cavernous malformations .
Microsurgical treatment of infratentorial malformations .
Stereotactic radiosurgery for management of deep brain cavernous malformations .
Interferon-antibodies and the breakthrough phenomenon during ribavirin/interferon-alpha combination therapy and interferon-alpha monotherapy of patients with chronic hepatitis C .
Treatment of Barrett esophagus with argon plasma coagulation with acid suppression -- a prospective study
Transmural drainage of pancreatic fluid collections without electrocautery using the Seldinger technique .
Echocardiography-guided ethanol septal reduction for hypertrophic obstructive cardiomyopathy .
Alterations of monocyte function in patients with growth hormone ( GH ) deficiency : effect of substitutive GH therapy .
Medical treatments for balding in men .
Carbon monoxide poisoning treated with hyperbaric oxygen : metabolic acidosis as a predictor of treatment requirements .
Medication received by patients with depression following the acute episode : adequacy and relation to outcome .
Splenectomy during pregnancy : an option in the treatment of autoimmune thrombocytopenic purpura .
Melatonin treatment of sleep-wake cycle disorders in children and adolescents .
Randomized phase II study of the neurokinin 1 receptor antagonist CJ-11 , 974 in the control of cisplatin-induced emesis .
Cataract surgery and its effect on intraocular pressure .
The outcome of arthroscopic treatment of temporomandibular joint arthropathy .
Neostigmine for acute colonic pseudo-obstruction .
A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure .
Surgical management of severe secondary peritonitis .
Early surgical treatment for supratentorial intracerebral hemorrhage : a randomized feasibility study .
Evaluation of clomipramine as an adjunct to behavioural therapy in the treatment of separation-related problems in dogs .
NICE to rule on influenza flu drug zanamivir .
Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer .
Treatment of hypertension with ascorbic acid .
Postoperative peritonitis originating from the duodenum : operative management by intubation and continuous intraluminal irrigation .
Efficacy of open-bite treatment with the Thera-spoon .
Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer .
Waiting for the definitive trial of hepatic arterial chemotherapy for colorectal cancer .
Phase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer : a gynecologic oncology group study .
Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage .
Treatment of Parkinson 's disease should begin with a dopamine agonist .
Low-molecular-weight heparin vs heparin in the treatment of patients with pulmonary embolism .
Radiotherapy in breast-conserving treatment for ductal carcinoma in situ : first results of the EORTC randomised phase III trial 10853 .
Methadone maintenance vs 180-day psychosocially enriched detoxification for treatment of opioid dependence : a randomized controlled trial .
Cryogen spray cooling during Nd : YAG laser treatment of hemangiomas .
Gene therapy for cancer .
Dry powdered formoterol , twice a day versus aerosolized salbutamol , four times a day , in patients with stable asthma
Celecoxib for arthritis .
Mesh plug repair and groin hernia surgery .
Brimonidine tartrate 0.2 % twice daily vs timolol 0.5 % twice daily : 1-year results in glaucoma patients .
Ticarcillin/clavulanate versus imipenem/cilistatin for the treatment of infections associated with gangrenous and perforated appendicitis .
Issues and challenges with antithrombotic therapy in diabetic patients with acute coronary syndromes .
Epoetin : a pharmacoeconomic review of its use in chronic renal failure and its effects on quality of life .
Rationale for the use of antiplatelet drugs in patients with peripheral vascular disease .
The fluoroquinolones for urinary tract infections : a review .
Reduction of vasoreactivity and thrombogenicity with laser-thermal angioplasty : comparison with balloon angioplasty .
High-dose chemotherapy with autologous stem-cell support for epithelial ovarian cancer .
Pelvic floor stimulation in the treatment of adult urinary incontinence .
Chronic vagus nerve stimulation for treatment of seizures .
`` Tandem '' high-dose chemoradiotherapy with autologous stem-cell support in the treatment of newly diagnosed or responsive multiple myeloma .
Special report : comparative efficacy of different types of pneumatic compression pumps for the treatment of lymphedema .
Special report : pressure-reducing support surfaces in the prevention and treatment of pressure ulcers : group 1 technologies .
Intravenous immune globulin for recurrent spontaneous abortion .
External counterpulsation for treatment of chronic stable angina pectoris .
Intra-articular hyaluronan injections for treatment of osteoarthritis of the knee .