| PROTEIN 1 | INTERACTION VERB | PROTEIN 2 | FREQUENCY |
| P-glycoprotein | inhibited | P-glycoprotein | 900 |
| IGF-I | binds | IGF-I | 648 |
| alpha 2-macroglobulin | inhibited | alpha 2-macroglobulin | 625 |
| p-gp | bind | p-gp | 288 |
| progesterone receptor | inhibit | oxytocin receptor | 270 |
| insulin receptor | bind | insulin receptor | 256 |
| LDL) receptor-related protein | activated | alpha 2-macroglobulin | 250 |
| TNF alpha | inhibited | TNF alpha | 180 |
| TNF-alpha | inhibited | TNF-alpha | 180 |
| CYP1A1 | inhibited | CYP1A1 | 144 |
| heparin cofactor II | inhibited | antithrombin III | 144 |
| ICAM-1 | bind | LFA-1 | 144 |
| IGF-II | binds | IGF-I | 144 |
| P-gp | inhibit | P-gp | 144 |
| transcription factor | activated | transcription factor | 144 |
| Calreticulin | inhibit | androgen receptor | 140 |
| transcription factor | activated | androgen receptor | 120 |
| IGFBP-3 | binds | IGF-I | 108 |
| androgen receptor | activated | androgen receptor | 100 |
| CYP1A2 | inhibited | CYP1A1 | 96 |
| E-selectin | inhibit | P-selectin | 90 |
| E-selectin | inhibited | vascular cell adhesion molecule-1 | 90 |
| E-selectin | inhibited | E-selectin | 81 |
| beta 2-microglobulin | inhibited | ICAM-1 | 72 |
| G-CSF | activated | transcription factor | 72 |
| ICAM-1 | inhibit | ICAM-1 | 72 |
| ICAM-1 | inhibited | ICAM-1 | 72 |
| ICAM-1 | inhibiting | LFA-1 | 72 |
| IGF-I | binds | IGF-II | 72 |
| LFA-1 | activated | ICAM-1 | 72 |
| PAI-1 | bind | PAI-1 | 72 |
| transcription factor | binding | AP-1 | 72 |
| transcription factor | binding | NF-IL6 | 72 |
| transcription factor | binding | serum response factor | 72 |
| alpha 2-macroglobulin receptor | binds | alpha 2-macroglobulin receptor | 64 |
| PF4 | inhibited | PF4 | 64 |
| intercellular adhesion molecule-1 | inhibited | vascular cell adhesion molecule-1 | 60 |
| Bradykinin | activates | GTP-binding protein | 58 |
| chloride channel | activated | glutamate receptor | 54 |
| E-selectin | inhibiting | L-selectin | 54 |
| von Willebrand factor | activated | thrombin receptor | 54 |
| Neuropeptide Y | inhibited | neuropeptide Y | 49 |
| Somatostatin | inhibits | Somatostatin | 49 |
| antithrombin III | inhibited | platelet factor 4 | 48 |
| ACTH | inhibited | ACTH | 48 |
| C/EBP beta | bind | C/EBP alpha | 48 |
| IL-3 | activated | transcription factor | 48 |
| IgE | bind | IgE | 45 |
| HSPG | bind | NCAM | 40 |
| protein S | inhibits | protein C | 40 |
| CD40L | activated | CD40L | 36 |
| CNTF | activated | CNTF | 36 |
| factor VIII | activated | factor VIII | 36 |
| ICAM-1 | bind | ICAM-1 | 36 |
| ICAM-1 | inhibits | ICAM-1 | 36 |
| IgM | inhibited | C5a | 36 |
| IGF-I | inhibit | HGF receptor | 36 |
| IGF-I | inhibit | IGF-I | 36 |
| IGF-I | inhibit | IGF-II | 36 |
| IGF-I | inhibited | IGF-II | 36 |
| IGF-I | inhibited | TNF-alpha | 36 |
| IGFBP-3 | bind | IGF-I | 36 |
| IGFBP-3 | binds | IGF-II | 36 |
| L-selectin | bind | L-selectin | 36 |
| L-selectin | inhibit | L-selectin | 36 |
| L-selectin | inhibiting | L-selectin | 36 |
| NF-kappa B | activate | transcription factor | 36 |
| NF-kappa B | activated | transcription factor | 36 |
| NF-kappa B | binds | TATA-binding protein | 36 |
| NF-kappa B | inhibited | transcription factor | 36 |
| NF-kappa B | inhibiting | transcription factor | 36 |
| transcription factor | binding | NF kappa B | 36 |
| transcription factor | binding | NF-kappa B | 36 |
| transcription factor | binds | PCNA | 36 |
| tumor necrosis factor | inhibit | TNF-alpha | 36 |
| TNF alpha | activate | TNF alpha | 36 |
| TNF alpha | inhibits | TNF alpha | 36 |
| TNF-alpha | inhibiting | TNF-alpha | 36 |
| TNF)-alpha | inhibit | TNF-alpha | 36 |
| calmodulin | activated | calmodulin | 32 |
| transcription factor Sp1 | bind | TATA box-binding protein | 32 |
| AP-1 | activated | androgen receptor | 30 |
| cyclin D1 | inhibit | PCNA | 30 |
| protein C | inhibit | factor VIII | 30 |
| vascular cell adhesion molecule-1 | activated | NF-kappa B | 30 |
| Vasopressin | activates | GTP-binding protein | 29 |
| Annexin V | inhibited | histone H1 | 28 |
| E-selectin | activated | NF-kappa B | 27 |
| GnRH | inhibited | GnRH | 27 |
| colony stimulating factor-1 | activated | DNA-binding protein | 25 |
| alpha 1-antitrypsin | inhibit | beta-thromboglobulin | 24 |
| antithrombin III | inhibiting | tissue factor | 24 |
| CYP2E1 | inhibited | CYP1A2 | 24 |
| IGFBP-2 | inhibit | IGF-I | 24 |
| IGFBP-3 | bind | IGF-II | 24 |
| protein S | inhibit | factor VIII | 24 |
| transcription factor | activated | IL-3 | 24 |
| tumor necrosis factor-alpha | inhibited | intercellular adhesion molecule-1 | 24 |
| tumor necrosis factor-alpha | inhibited | TNF-alpha | 24 |
| TNF alpha | inhibited | GM-CSF | 24 |
| TNF-alpha | activate | p53 protein | 24 |
| TNF-alpha | inhibited | GM-CSF | 24 |
| vascular cell adhesion molecule-1 | inhibited | VCAM-1 | 20 |
| factor VIII | activated | factor Xa | 18 |
| granulocyte-macrophage colony stimulating factor | inhibited | beta-thromboglobulin | 18 |
| G-CSF | inhibit | tumor necrosis factor | 18 |
| G-CSF | inhibited | TNF-alpha | 18 |
| NF kappa B | activated | tumor necrosis factor | 18 |
| NF kappa B | inhibit | TNF-alpha | 18 |
| potassium channel | activated | G protein | 18 |
| potassium channel | activated | G-protein | 18 |
| tumor necrosis factor | activated | NF-kappa B | 18 |
| tumor necrosis factor | activates | NF-kappa B | 18 |
| TNF-alpha | activated | NF-kappa B | 18 |
| TNF-alpha | inhibited | NF)-kappa B | 18 |
| GM-CSF | activated | GM-CSF | 16 |
| GM-CSF | bind | GM-CSF | 16 |
| GM-CSF | inhibited | GM-CSF | 16 |
| GM-CSF | inhibited | tumor necrosis factor-alpha | 16 |
| IGF-1 | inhibited | IGF-1 | 16 |
| IGF-1 | inhibiting | IGF-1 | 16 |
| IL-3 | inhibited | IL-3 | 16 |
| IL3 | inhibit | IL3 | 16 |
| NGF | inhibited | NGF | 16 |
| protein S | bind | protein S | 16 |
| protein S | inhibits | protein S | 16 |
| retinoic acid receptor | activated | retinoic acid receptor | 16 |
| tumor necrosis factor-alpha | inhibited | lymphocyte function-associated antigen-1 | 16 |
| binding protein | bind | integrin alpha-subunits | 15 |
| antithrombin III | inhibit | factor Xa | 12 |
| Bradykinin | inhibited | bradykinin | 12 |
| EGF receptor | activate | G protein | 12 |
| factor VIII | bind | protein S | 12 |
| Galectin-3 | bind | carcinoembryonic antigen | 12 |
| IGFBP-3 | inhibit | IGF-I | 12 |
| IGFBP-5 | inhibited | IGF-I | 12 |
| IGFBP-5 | inhibited | IGF-II | 12 |
| IGFBP-6 | binds | IGF II | 12 |
| IL-3 | inhibited | TNF-alpha | 12 |
| protein S | inhibits | factor VIII | 12 |
| PAI-1 | bind | PAI-2 | 12 |
| PAI-2 | bind | PAI-1 | 12 |
| CYP2D6 | inhibited | CYP2D6 | 9 |
| eIF-2 | inhibits | eIF-2 alpha | 9 |
| E2 protein | activate | E2 protein | 9 |
| Factor IX | bind | Factor IX | 9 |
| G-CSF | inhibited | G-CSF | 9 |
| GnRH receptor | binds | GnRH | 9 |
| IgD | inhibits | IgD | 9 |
| IgE | inhibit | IgE | 9 |
| NF kappa B | inhibit | NF kappa B | 9 |
| NF-kappa B | activates | NF-kappa B | 9 |
| NF-kappa B | inhibited | AP-1 | 9 |
| NF-kappa B | inhibitor | NF-kappa B | 9 |
| AL-1 | activated | AL-1 | 8 |
| IGF-1 | inhibited | IGF-1 receptor | 8 |
| IGFBP-5 | inhibited | IGFBP-5 | 8 |
| IL3 | inhibits | IL-3 | 8 |
| platelet factor 4 | activated | C3a | 8 |
| tumor necrosis factor-alpha | activate | activator protein-1 | 8 |
| neuropeptide Y | inhibits | alpha-melanocyte-stimulating hormone | 7 |
| alpha 3-integrin | inhibited | ICAM-1 | 6 |
| IGF-I | inhibited | IGFBP-4 | 6 |
| IGF-I | inhibited | IGFBP-5 | 6 |
| IGF-II | bind | mannose 6-phosphate receptor | 6 |
| IGF-II | inhibit | IGFBP-5 | 6 |
| IGFBP-1 | inhibit | IGF-I | 6 |
| IGFBP-1 | inhibited | IGF-I | 6 |
| IGFBP-4 | bind | IGF-I | 6 |
| IGFBP-4 | bind | IGF-II | 6 |
| platelet-derived growth factor | inhibit | HGF receptor | 6 |
| Platelet derived growth factor | inhibited | TNF-alpha | 6 |
| Properdin | bind | C3b | 6 |
| Substance P | activate | Substance P receptor | 6 |
| LDL-lipoproteins | bind | LDL-receptor | 5 |
| substance P | inhibited | substance P | 5 |
| substance P | inhibits | corticotropin-releasing hormone | 5 |
| ACTH | inhibited | alpha-MSH | 4 |
| ASGP-R | inhibited | ASGP-R | 4 |
| colony-stimulating factor-1 | inhibited | tumor necrosis factor-alpha | 4 |
| C5a | inhibited | C5a | 4 |
| dopamine receptor | binds | dopamine receptor | 4 |
| dopamine receptor | inhibits | dopamine receptor | 4 |
| IGFBP-3 | bind | IGFBP-3 | 4 |
| IGFBP-3 | inhibit | IGFBP-3 | 4 |
| IL-3 | inhibit | C5a | 4 |
| IRE-BP | bind | IRE-BP | 4 |
| kappa-opioid receptor | activate | G protein | 4 |
| membrane protein | inhibited | IGFBP-5 | 4 |
| protein S | inhibited | factor Xa | 4 |
| PAI-2 | bind | PAI-2 | 4 |
| Prothrombin | activated | factor Xa | 4 |
| tumor necrosis factor alpha | inhibited | interferon gamma | 4 |
| Vasopressin | activates | calmodulin | 4 |
| factor Xa | bind | factor Xa | 3 |
| factor Xa | binds | Factor Xa | 3 |
| factor Xa | inhibited | factor Xa | 3 |
| granulocyte-macrophage colony stimulating factor | inhibited | interferon-gamma | 3 |
| granulocyte-macrophage colony-stimulating factor | inhibited | interferon-gamma | 3 |
| macrophage colony-stimulating factor | activate | NF-kappa B | 3 |
| C1 | inhibited | C1 | 2 |
| CYP2B1 | inhibited | CYP2B1 | 2 |
| factor V | inhibit | factor V | 2 |
| factor Xa | bind | Factor Xa | 2 |
| IGFBP-2 | inhibiting | IGFBP-1 | 2 |
| IGFBP-4 | inhibited | IGFBP-4 | 2 |
| IGFBP-5 | inhibited | IGFBP-1 | 2 |
| IGFBP-6 | binds | IGFBP-3 | 2 |
| substance P | inhibiting | NK-1 receptor | 2 |
| Substance P | inhibited | substance P | 2 |
| corticotropin-releasing factor | inhibited | alpha-melanocyte-stimulating hormone | 1 |
| C1q | bind | C1q | 1 |
| C1q | inhibited | C1q | 1 |
| C3b | inhibited | C3b | 1 |
| Calcitonin gene-related peptide | inhibit | somatostatin-14 | 1 |
| factor Xa | inhibit | factor Xa | 1 |
| factor Xa | inhibits | factor Xa | 1 |
| Fc receptor | inhibited | Fc receptor | 1 |
| Hageman factor | activated | Hageman factor | 1 |
| Hageman factor | inhibit | Hageman factor | 1 |
| interferon-gamma | bind | interferon-gamma | 1 |
| IGFBP 5 | inhibited | IGFBP 4 | 1 |
| IGFBP-5 | inhibit | IGFBP-5 | 1 |
| nuclear protein | binds | nuclear protein | 1 |
| platelet-derived growth factor | inhibit | platelet-derived growth factor | 1 |
| substance P | inhibit | substance P | 1 |
| substance P | inhibiting | substance P | 1 |